Perineuronal Net Receptor PTP sigma Regulates Retention of Memories

Show simple item record Lesnikova, Angelina Casarotto, Plinio Moliner, Rafael Fred, Senem Merve Biojone, Caroline Castren, Eero 2021-10-12T04:50:03Z 2021-10-12T04:50:03Z 2021-07-22
dc.identifier.citation Lesnikova , A , Casarotto , P , Moliner , R , Fred , S M , Biojone , C & Castren , E 2021 , ' Perineuronal Net Receptor PTP sigma Regulates Retention of Memories ' , Frontiers in Synaptic Neuroscience , vol. 13 , 672475 .
dc.identifier.other PURE: 169370277
dc.identifier.other PURE UUID: 447c270d-3979-48e8-b304-3ae958162ea2
dc.identifier.other WOS: 000689291000001
dc.identifier.other ORCID: /0000-0003-1992-5014/work/101302552
dc.identifier.other ORCID: /0000-0002-1402-2791/work/101362387
dc.identifier.other ORCID: /0000-0002-1090-4631/work/101365420
dc.description.abstract Perineuronal nets (PNNs) have an important physiological role in the retention of learning by restricting cognitive flexibility. Their deposition peaks after developmental periods of intensive learning, usually in late childhood, and they help in long-term preservation of newly acquired skills and information. Modulation of PNN function by various techniques enhances plasticity and regulates the retention of memories, which may be beneficial when memory persistence entails negative symptoms such as post-traumatic stress disorder (PTSD). In this study, we investigated the role of PTP sigma [receptor-type tyrosine-protein phosphatase S, a phosphatase that is activated by binding of chondroitin sulfate proteoglycans (CSPGs) from PNNs] in retention of memories using Novel Object Recognition and Fear Conditioning models. We observed that mice haploinsufficient for PTPRS gene (PTP sigma(+/-)), although having improved short-term object recognition memory, display impaired long-term memory in both Novel Object Recognition and Fear Conditioning paradigm, as compared to WT littermates. However, PTP sigma(+/-) mice did not show any differences in behavioral tests that do not heavily rely on cognitive flexibility, such as Elevated Plus Maze, Open Field, Marble Burying, and Forced Swimming Test. Since PTP sigma has been shown to interact with and dephosphorylate TRKB, we investigated activation of this receptor and its downstream pathways in limbic areas known to be associated with memory. We found that phosphorylation of TRKB and PLC gamma are increased in the hippocampus, prefrontal cortex, and amygdaloid complex of PTP sigma(+/-) mice, but other TRKB-mediated signaling pathways are not affected. Our data suggest that PTP sigma downregulation promotes TRKB phosphorylation in different brain areas, improves short-term memory performance but disrupts long-term memory retention in the tested animal models. Inhibition of PTP sigma or disruption of PNN-PTP sigma-TRKB complex might be a potential target for disorders where negative modulation of the acquired memories can be beneficial. en
dc.format.extent 13
dc.language.iso eng
dc.relation.ispartof Frontiers in Synaptic Neuroscience
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject memory
dc.subject perineuronal nets
dc.subject plasticity
dc.subject PNNs
dc.subject PTPRS
dc.subject BDNF
dc.subject Ntrk2
dc.subject TrkB
dc.subject MICE LACKING
dc.subject TRKB
dc.subject NEURONS
dc.subject HIPPOCAMPUS
dc.subject 3112 Neurosciences
dc.title Perineuronal Net Receptor PTP sigma Regulates Retention of Memories en
dc.type Article
dc.contributor.organization Neuroscience Center
dc.contributor.organization Helsinki Institute of Life Science HiLIFE
dc.description.reviewstatus Peer reviewed
dc.relation.issn 1663-3563
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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