Metabolomic signature of amino acids in plasma of patients with non-segmental Vitiligo

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dc.contributor.author Marzabani, Rezvan
dc.contributor.author Rezadoost, Hassan
dc.contributor.author Choopanian, Peyman
dc.contributor.author Kolahdooz, Sima
dc.contributor.author Mozafari, Nikoo
dc.contributor.author Mirzaie, Mehdi
dc.contributor.author Karimi, Mehrdad
dc.contributor.author Nieminen, Anni
dc.contributor.author Jafari, Mohieddin
dc.date.accessioned 2021-10-12T05:07:01Z
dc.date.available 2021-10-12T05:07:01Z
dc.date.issued 2021-10
dc.identifier.citation Marzabani , R , Rezadoost , H , Choopanian , P , Kolahdooz , S , Mozafari , N , Mirzaie , M , Karimi , M , Nieminen , A & Jafari , M 2021 , ' Metabolomic signature of amino acids in plasma of patients with non-segmental Vitiligo ' , Metabolomics , vol. 17 , no. 10 , 92 . https://doi.org/10.1007/s11306-021-01843-x
dc.identifier.other PURE: 169370544
dc.identifier.other PURE UUID: a3c194a1-d7d2-4870-bc41-23eb8136824e
dc.identifier.other WOS: 000699015800002
dc.identifier.other ORCID: /0000-0002-6991-8587/work/101365626
dc.identifier.uri http://hdl.handle.net/10138/335165
dc.description.abstract Introduction Vitiligo pathogenesis is complicated, and several possibilities were suggested. However, it is well-known that the metabolism of pigments plays a significant role in the pathogenicity of the disease. Objectives We explored the role of amino acids in vitiligo using targeted metabolomics. Methods The amino acid profile was studied in plasma using liquid chromatography. First, 22 amino acids were derivatized and precisely determined. Next, the concentrations of the amino acids and the molar ratios were calculated in 31 patients and 34 healthy individuals. Results The differential concentrations of amino acids were analyzed and eight amino acids, i.e., cysteine, arginine, lysine, ornithine, proline, glutamic acid, histidine, and glycine were observed differentially. The ratios of cysteine, glutamic acid, and proline increased significantly in Vitiligo patients, whereas arginine, lysine, ornithine, glycine, and histidine decreased significantly compared to healthy individuals. Considering the percentage of skin area, we also showed that glutamic acid significantly has a higher amount in patients with less than 25% involvement compared to others. Finally, cysteine and lysine are considered promising candidates for diagnosing and developing the disorder with high accuracy (0.96). Conclusion The findings are consistent with the previously illustrated mechanism of Vitiligo, such as production deficiency in melanin and an increase in immune activity and oxidative stress. Furthermore, new evidence was provided by using amino acids profile toward the pathogenicity of the disorder. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Metabolomics
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Vitiligo
dc.subject Plasma
dc.subject Metabolomics
dc.subject Amino acids
dc.subject Liquid chromatography
dc.subject UROCANIC ACID
dc.subject GLUTAMATE
dc.subject PHOTORECEPTOR
dc.subject HOMOCYSTEINE
dc.subject BIOMARKERS
dc.subject ARGINASE
dc.subject GENETICS
dc.subject PROLINE
dc.subject ANXIETY
dc.subject SKIN
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Metabolomic signature of amino acids in plasma of patients with non-segmental Vitiligo en
dc.type Article
dc.contributor.organization Research Program in Systems Oncology
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Helsinki Institute of Life Science HiLIFE
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1007/s11306-021-01843-x
dc.relation.issn 1573-3882
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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