Inheritance and flexibility of cell polarity : a clue for understanding human brain development and evolution

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http://hdl.handle.net/10138/335166

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Kalebic , N & Namba , T 2021 , ' Inheritance and flexibility of cell polarity : a clue for understanding human brain development and evolution ' , Development , vol. 148 , no. 17 , 199417 . https://doi.org/10.1242/dev.199417

Titel: Inheritance and flexibility of cell polarity : a clue for understanding human brain development and evolution
Författare: Kalebic, Nereo; Namba, Takashi
Upphovmannens organisation: Neuroscience Center
Helsinki Institute of Life Science HiLIFE
Datum: 2021-09
Språk: eng
Sidantal: 13
Tillhör serie: Development
ISSN: 0950-1991
DOI: https://doi.org/10.1242/dev.199417
Permanenta länken (URI): http://hdl.handle.net/10138/335166
Abstrakt: Cell polarity is fundamentally important for understanding brain development. Here, we hypothesize that the inheritance and flexibility of cell polarity during neocortex development could be implicated in neocortical evolutionary expansion. Molecular and morphological features of cell polarity may be inherited from one type of progenitor cell to the other and finally transmitted to neurons. Furthermore, key cell types, such as basal progenitors and neurons, exhibit a highly flexible polarity. We suggest that both inheritance and flexibility of cell polarity are implicated in the amplification of basal progenitors and tangential dispersion of neurons, which are key features of the evolutionary expansion of the neocortex.
Subject: Brain development
Brain evolution
Cell polarity
Neural stem cell
Neuronal polarity
OUTER SUBVENTRICULAR ZONE
RADIAL GLIAL-CELLS
CEREBRAL-CORTEX DEVELOPMENT
NEURONAL MIGRATION
PROGENITOR CELLS
NEURAL STEM
NEUROEPITHELIAL CELLS
ASYMMETRIC DIVISION
CORTICAL-NEURONS
BASAL PROCESS
1184 Genetics, developmental biology, physiology
Referentgranskad: Ja
Licens: cc_by
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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