Inheritance and flexibility of cell polarity : a clue for understanding human brain development and evolution

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dc.contributor.author Kalebic, Nereo
dc.contributor.author Namba, Takashi
dc.date.accessioned 2021-10-12T05:13:01Z
dc.date.available 2021-10-12T05:13:01Z
dc.date.issued 2021-09
dc.identifier.citation Kalebic , N & Namba , T 2021 , ' Inheritance and flexibility of cell polarity : a clue for understanding human brain development and evolution ' , Development , vol. 148 , no. 17 , 199417 . https://doi.org/10.1242/dev.199417
dc.identifier.other PURE: 169370718
dc.identifier.other PURE UUID: 83f6123f-9608-4c3d-8029-4ad3d1ea9218
dc.identifier.other WOS: 000696114300004
dc.identifier.other ORCID: /0000-0003-4875-666X/work/101303388
dc.identifier.uri http://hdl.handle.net/10138/335166
dc.description.abstract Cell polarity is fundamentally important for understanding brain development. Here, we hypothesize that the inheritance and flexibility of cell polarity during neocortex development could be implicated in neocortical evolutionary expansion. Molecular and morphological features of cell polarity may be inherited from one type of progenitor cell to the other and finally transmitted to neurons. Furthermore, key cell types, such as basal progenitors and neurons, exhibit a highly flexible polarity. We suggest that both inheritance and flexibility of cell polarity are implicated in the amplification of basal progenitors and tangential dispersion of neurons, which are key features of the evolutionary expansion of the neocortex. en
dc.format.extent 13
dc.language.iso eng
dc.relation.ispartof Development
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Brain development
dc.subject Brain evolution
dc.subject Cell polarity
dc.subject Neural stem cell
dc.subject Neuronal polarity
dc.subject OUTER SUBVENTRICULAR ZONE
dc.subject RADIAL GLIAL-CELLS
dc.subject CEREBRAL-CORTEX DEVELOPMENT
dc.subject NEURONAL MIGRATION
dc.subject PROGENITOR CELLS
dc.subject NEURAL STEM
dc.subject NEUROEPITHELIAL CELLS
dc.subject ASYMMETRIC DIVISION
dc.subject CORTICAL-NEURONS
dc.subject BASAL PROCESS
dc.subject 1184 Genetics, developmental biology, physiology
dc.title Inheritance and flexibility of cell polarity : a clue for understanding human brain development and evolution en
dc.type Article
dc.contributor.organization Neuroscience Center
dc.contributor.organization Helsinki Institute of Life Science HiLIFE
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1242/dev.199417
dc.relation.issn 0950-1991
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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