Coagulopathy in Acute Puumala Hantavirus Infection

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http://hdl.handle.net/10138/335171

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Koskela , S , Mäkelä , S , Strandin , T , Vaheri , A , Outinen , T , Joutsi-Korhonen , L , Pörsti , I , Mustonen , J & Laine , O 2021 , ' Coagulopathy in Acute Puumala Hantavirus Infection ' , Viruses-Basel , vol. 13 , no. 8 , 1553 . https://doi.org/10.3390/v13081553

Title: Coagulopathy in Acute Puumala Hantavirus Infection
Author: Koskela, Sirpa; Mäkelä, Satu; Strandin, Tomas; Vaheri, Antti; Outinen, Tuula; Joutsi-Korhonen, Lotta; Pörsti, Ilkka; Mustonen, Jukka; Laine, Outi
Contributor: University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, HUSLAB
Date: 2021-08
Language: eng
Number of pages: 15
Belongs to series: Viruses-Basel
ISSN: 1999-4915
URI: http://hdl.handle.net/10138/335171
Abstract: Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein-kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and thrombosis.
Subject: Puumala hantavirus
coagulation
complement system
fibrinolysis
endothelium
platelet
acute kidney injury
DIC
LONG PENTRAXIN PTX3
HEMORRHAGIC-FEVER
RENAL SYNDROME
NITRIC-OXIDE
NEPHROPATHIA-EPIDEMICA
COMPLEMENT ACTIVATION
THROMBIN GENERATION
ENDOTHELIAL-CELLS
INNATE IMMUNITY
THROMBOCYTOPENIA
3111 Biomedicine
11832 Microbiology and virology
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