Koskela , S , Mäkelä , S , Strandin , T , Vaheri , A , Outinen , T , Joutsi-Korhonen , L , Pörsti , I , Mustonen , J & Laine , O 2021 , ' Coagulopathy in Acute Puumala Hantavirus Infection ' , Viruses (Basel) , vol. 13 , no. 8 , 1553 . https://doi.org/10.3390/v13081553
Title: | Coagulopathy in Acute Puumala Hantavirus Infection |
Author: | Koskela, Sirpa; Mäkelä, Satu; Strandin, Tomas; Vaheri, Antti; Outinen, Tuula; Joutsi-Korhonen, Lotta; Pörsti, Ilkka; Mustonen, Jukka; Laine, Outi |
Contributor organization: | Medicum Department of Virology Viral Zoonosis Research Unit HUSLAB Department of Diagnostics and Therapeutics |
Date: | 2021-08 |
Language: | eng |
Number of pages: | 15 |
Belongs to series: | Viruses (Basel) |
ISSN: | 1999-4915 |
DOI: | https://doi.org/10.3390/v13081553 |
URI: | http://hdl.handle.net/10138/335171 |
Abstract: | Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein-kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and thrombosis. |
Subject: |
Puumala hantavirus
coagulation complement system fibrinolysis endothelium platelet acute kidney injury DIC LONG PENTRAXIN PTX3 HEMORRHAGIC-FEVER RENAL SYNDROME NITRIC-OXIDE NEPHROPATHIA-EPIDEMICA COMPLEMENT ACTIVATION THROMBIN GENERATION ENDOTHELIAL-CELLS INNATE IMMUNITY THROMBOCYTOPENIA 3111 Biomedicine 11832 Microbiology and virology |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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