Adipose tissue steroid receptor rna activator 1 (Sra1) expression is associated with obesity, insulin resistance, and inflammation

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Kochumon , S , Arefanian , H , Sindhu , S , Shenouda , S , Thomas , R , Al-Mulla , F , Tuomilehto , J & Ahmad , R 2021 , ' Adipose tissue steroid receptor rna activator 1 (Sra1) expression is associated with obesity, insulin resistance, and inflammation ' , Cells , vol. 10 , no. 10 , 2602 . https://doi.org/10.3390/cells10102602

Title: Adipose tissue steroid receptor rna activator 1 (Sra1) expression is associated with obesity, insulin resistance, and inflammation
Author: Kochumon, Shihab; Arefanian, Hossein; Sindhu, Sardar; Shenouda, Steve; Thomas, Reeby; Al-Mulla, Fahd; Tuomilehto, Jaakko; Ahmad, Rasheed
Contributor: University of Helsinki, Clinicum
Date: 2021-10
Language: eng
Number of pages: 15
Belongs to series: Cells
ISSN: 2073-4409
URI: http://hdl.handle.net/10138/335270
Abstract: Steroid receptor RNA activator 1 (SRA1) is involved in pathophysiological responses of adipose tissue (AT) in obesity. In vitro and animal studies have elucidated its role in meta-inflammation. Since SRA1 AT expression in obesity/type 2 diabetes (T2D) and the relationship with immune-metabolic signatures remains unclear, we assessed AT SRA1 expression and its association with immune–metabolic markers in individuals with obesity/T2D. For this, 55 non-diabetic and 53 T2D individuals classified as normal weight (NW; lean), overweight, and obese were recruited and fasting blood and subcutaneous fat biopsy samples were collected. Plasma metabolic markers were assessed using commercial kits and AT expression of SRA1 and selected immune markers using RT-qPCR. SRA1 expression was significantly higher in non-diabetic obese compared with NW individuals. SRA1 expression associated with BMI, PBF, serum insulin, and HOMA-IR in the total study population and people without diabetes. SRA1 associated with waist circumference in people without diabetes and NW participants, whereas it associated inversely with HbA1c in overweight participants. In most study subgroups AT SRA1 expression associated directly with CXCL9, CXCL10, CXCL11, TNF-α, TGF-β, IL2RA, and IL18, but inversely with CCL19 and CCR2. TGF-β/IL18 independently predicted the SRA1 expression in people without diabetes and in the total study population, while TNF-α/IL-2RA predicted SRA1 only in people with diabetes. TNF-α also predicted SRA1 in both NW and obese people regardless of the diabetes status. In conclusion, AT SRA1 expression is elevated in people with obesity which associates with typical immunometabolic markers of obesity/T2D, implying that SRA1 may have potential as a biomarker of metabolic derangements.
Subject: Adipose tissue
Inflammation
Insulin resistance
Obesity
Steroid receptor RNA activator 1/SRA1
Type 2 diabetes
3121 General medicine, internal medicine and other clinical medicine
3142 Public health care science, environmental and occupational health
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