The relation between caffeine consumption and endometriosis : An updated systematic review and meta-analysis

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Kechagias , K S , Triantafyllidis , K K , Kyriakidou , M , Giannos , P , Kalliala , I , Veroniki , A A , Paraskevaidi , M & Kyrgiou , M 2021 , ' The relation between caffeine consumption and endometriosis : An updated systematic review and meta-analysis ' , Nutrients , vol. 13 , no. 10 , 3457 . https://doi.org/10.3390/nu13103457

Title: The relation between caffeine consumption and endometriosis : An updated systematic review and meta-analysis
Author: Kechagias, Konstantinos S.; Triantafyllidis, Konstantinos Katsikas; Kyriakidou, Margarita; Giannos, Panagiotis; Kalliala, Ilkka; Veroniki, Areti Angeliki; Paraskevaidi, Maria; Kyrgiou, Maria
Contributor: University of Helsinki, Clinicum
Date: 2021-10
Language: eng
Number of pages: 12
Belongs to series: Nutrients
ISSN: 2072-6643
URI: http://hdl.handle.net/10138/335271
Abstract: While the contributing factors leading to endometriosis remain unclear, its clinical heterogeneity suggests a multifactorial causal background. Amongst others, caffeine has been studied extensively during the last decade as a putative contributing factor. In this systematic review and meta-analysis, we provide an overview/critical appraisal of studies that report on the association between caffeine consumption and the presence of endometriosis. In our search strategy, we screened PubMed and Scopus for human studies examining the above association. The main outcome was the relative risk of endometriosis in caffeine users versus women consuming little or no caffeine (<100 mg/day). Subgroup analyses were conducted for different levels of caffeine intake: high (>300 mg/day) or moderate (100–300 mg/day). Ten studies were included in the meta-analysis (five cohort and five case-control studies). No statistically significant association was observed between overall caffeine consumption and risk for endometriosis (RR 1.12, 95% confidence interval (CI) 0.97–1.28, I2 = 70%) when compared to little or no (<100 mg/day) caffeine intake. When stratified according to level of consumption, high intake was associated with increased risk of endometriosis (RR 1.30, 95%CI 1.04–1.63, I2 = 56%), whereas moderate intake did not reach nominal statistical significance (RR 1.18, 95%CI 0.99–1.40, I2 = 37%). In conclusion, caffeine consumption does not appear to be associated with increased risk for endometriosis. However, further research is needed to elucidate the potential dose-dependent link between caffeine and endometriosis or the probable role of caffeine intake as a measurement of other unidentified biases.
Subject: Caffeine
Caffeine-containing beverages
Coffee
Endometriosis
Environmental factors
Meta-analysis
Review
3123 Gynaecology and paediatrics
3143 Nutrition
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