Association between symptoms of depression, diabetes complications and vascular risk factors in four European cohorts of individuals with type 1 diabetes - InterDiane Consortium

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Ahola , A J , Radzeviciene , L , Zaharenko , L , Bulum , T , Skrebinska , S , Prakapiene , E , Blaslov , K , Roso , V , Rovite , V , Pirags , V , Duvnjak , L , Sokolovska , J , Verkauskiene , R & Forsblom , C 2020 , ' Association between symptoms of depression, diabetes complications and vascular risk factors in four European cohorts of individuals with type 1 diabetes - InterDiane Consortium ' , Diabetes Research and Clinical Practice , vol. 170 , 108495 . https://doi.org/10.1016/j.diabres.2020.108495

Title: Association between symptoms of depression, diabetes complications and vascular risk factors in four European cohorts of individuals with type 1 diabetes - InterDiane Consortium
Author: Ahola, Aila J.; Radzeviciene, Lina; Zaharenko, Linda; Bulum, Tomislav; Skrebinska, Sabine; Prakapiene, Edita; Blaslov, Kristina; Roso, Vinko; Rovite, Vita; Pirags, Valdis; Duvnjak, Lea; Sokolovska, Jelizaveta; Verkauskiene, Rasa; Forsblom, Carol
Other contributor: University of Helsinki, HUS Internal Medicine and Rehabilitation
University of Helsinki, Research Programs Unit








Date: 2020-12
Language: eng
Number of pages: 10
Belongs to series: Diabetes Research and Clinical Practice
ISSN: 0168-8227
DOI: https://doi.org/10.1016/j.diabres.2020.108495
URI: http://hdl.handle.net/10138/335288
Abstract: Aims: To investigate the association between depressive symptomatology and health markers in type 1 diabetes. Methods: Four countries from the InterDiane Consortium had adopted the Finnish Diabetic Nephropathy Study protocol, including the Beck Depression Inventory (BDI). Associations between depression symptomatology, diabetes complications (diabetic nephropathy, proliferative retinopathy, major adverse cardiovascular events [MACE]) and vascular risk factors (metabolic syndrome, body mass index, glycaemic control) were investigated. Results: In a sample of 1046 participants (Croatia n = 99; Finland n = 314; Latvia n = 315; Lithuania n = 318), 13.4% displayed symptoms of depression (BDI score 16) with no statistically significant difference in the prevalence of depression among the cohorts. The highest rates of diabetic nephropathy (37.1%) and proliferative retinopathy (36.3%) were observed in Lithuania. The rates of MACE and metabolic syndrome were highest in Finland. In joint analyses, individuals exhibiting depression symptomatology had higher HbA(1c) (79 vs. 72 mmol/mol, p <0.001) and higher triglyceride concentration (1.67 vs. 1.28 mmol/l, p <0.001), than those without. In the multivariable model, BDI score was positively associated with the presence of diabetic nephropathy, proliferative retinopathy, MACE, and metabolic syndrome and its triglyceride component. Moreover, BDI score was positively associated with the number of metabolic syndrome components, triglyceride concentration, and HbA(1c). Conclusions: Comorbid depression should be considered a relevant factor explaining metabolic problems and vascular outcomes. Causality cannot be inferred from this crosssectional study. (c) 2020 Elsevier B.V. All rights reserved.
Subject: Depression
Diabetes complications
Metabolic syndrome
Type 1 diabetes
METABOLIC SYNDROME
GLYCEMIC CONTROL
RETINOPATHY
ADULTS
DISEASE
HEALTH
CARE
3121 General medicine, internal medicine and other clinical medicine
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