Dual-Light Photodynamic Therapy Effectively Eliminates Streptococcus Oralis Biofilms

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Hentilä , J , Laakamaa , N , Sorsa , T , Meurman , J , Välimaa , H , Nikinmaa , S , Kankuri , E , Tauriainen , T & Pätilä , T 2021 , ' Dual-Light Photodynamic Therapy Effectively Eliminates Streptococcus Oralis Biofilms ' , Journal of Pharmacy and Pharmaceutical Sciences , vol. 24 , pp. 484-487 . https://doi.org/10.18433/jpps32084

Title: Dual-Light Photodynamic Therapy Effectively Eliminates Streptococcus Oralis Biofilms
Author: Hentilä, Jessica; Laakamaa, Noora; Sorsa, Timo; Meurman, Jukka; Välimaa, Hanna; Nikinmaa, Sakari; Kankuri, Esko; Tauriainen, Tuomas; Pätilä, Tommi
Contributor organization: Faculty of Medicine
Oral and Maxillofacial Surgery
HUS Head and Neck Center
Suu- ja leukakirurgian yksikkö
Department of Oral and Maxillofacial Diseases
Department of Virology
Department of Pharmacology
Esko Markus Kankuri / Principal Investigator
HUS Heart and Lung Center
III kirurgian klinikka
Children's Hospital
HUS Children and Adolescents
Date: 2021-09-22
Language: eng
Number of pages: 4
Belongs to series: Journal of Pharmacy and Pharmaceutical Sciences
ISSN: 1482-1826
DOI: https://doi.org/10.18433/jpps32084
URI: http://hdl.handle.net/10138/335296
Abstract: Purpose: During cancer treatment, oral mucositis due to radiotherapy or chemotherapy often leads to disruption of the oral mucosa, enabling microbes to invade bloodstream. Viridans streptococcal species are part of the healthy oral microbiota but can be frequently isolated from the blood of neutropenic patients. We have previously shown the antibacterial efficacy of dual-light, the combination of antibacterial blue light (aBL) and indocyanine green photodynamic therapy (aPDT). Methods: Here, we investigated the dual-light antibacterial action against four-day Streptococcus oralis biofilm. In addition, while keeping the total radiant exposure constant at 100J/cm(2), we investigated the effect of changing the different relative light energies of aBL and aPDT to the antibacterial potential. Results: The dual-light had a significant antibacterial effect in all the tested combinations. Conclusion: Dual-light can be used as an effective disinfectant against S. oralis biofilm.
Subject: 317 Pharmacy
116 Chemical sciences
Peer reviewed: Yes
Rights: cc_by_sa
Usage restriction: openAccess
Self-archived version: publishedVersion

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