Cobalt-Catalyzed alpha-Arylation of Substituted alpha-Bromo alpha-Fluoro beta-Lactams with Diaryl Zinc Reagents : Generalization to Functionalized Bromo Derivatives

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Lorion , M M , Koch , V , Nieger , M , Chen , H-Y , Lei , A , Bräse , S & Cossy , J 2020 , ' Cobalt-Catalyzed alpha-Arylation of Substituted alpha-Bromo alpha-Fluoro beta-Lactams with Diaryl Zinc Reagents : Generalization to Functionalized Bromo Derivatives ' , Chemistry: A European Journal , vol. 26 , no. 58 , pp. 13163-13169 . https://doi.org/10.1002/chem.202001721

Title: Cobalt-Catalyzed alpha-Arylation of Substituted alpha-Bromo alpha-Fluoro beta-Lactams with Diaryl Zinc Reagents : Generalization to Functionalized Bromo Derivatives
Author: Lorion, Melanie M.; Koch, Vanessa; Nieger, Martin; Chen, Hi-Yung; Lei, Aiwen; Bräse, Stefan; Cossy, Janine
Contributor organization: Department of Chemistry
Date: 2020-10-15
Language: eng
Number of pages: 7
Belongs to series: Chemistry: A European Journal
ISSN: 0947-6539
DOI: https://doi.org/10.1002/chem.202001721
URI: http://hdl.handle.net/10138/335329
Abstract: A cobalt-catalyzed cross-coupling of alpha-bromo alpha-fluoro beta-lactams with diarylzinc or diallylzinc reagents is herein disclosed. The protocol proved to be general, chemoselective and operationally simple allowing the C4 functionalization of beta-lactams. The substrate scope was expanded to alpha-bromo lactams and amides, alpha-bromo lactones and esters as well asN- and O-containing heterocycles.
Subject: beta-lactam
bis(organo)zinc reagents
catalysis
cobalt
cross-coupling
CROSS-COUPLING REACTIONS
AMIDES
116 Chemical sciences
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: acceptedVersion


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