Hantavirus Research in Finland : Highlights and Perspectives

Show full item record



Permalink

http://hdl.handle.net/10138/335338

Citation

Vaheri , A , Henttonen , H & Mustonen , J 2021 , ' Hantavirus Research in Finland : Highlights and Perspectives ' , Viruses (Basel) , vol. 13 , no. 8 , 1452 . https://doi.org/10.3390/v13081452

Title: Hantavirus Research in Finland : Highlights and Perspectives
Author: Vaheri, Antti; Henttonen, Heikki; Mustonen, Jukka
Contributor organization: Medicum
Department of Virology
Date: 2021-08
Language: eng
Number of pages: 14
Belongs to series: Viruses (Basel)
ISSN: 1999-4915
DOI: https://doi.org/10.3390/v13081452
URI: http://hdl.handle.net/10138/335338
Abstract: Finland has the highest incidence of hantavirus infections globally, with a significant impact on public health. The large coverage of boreal forests and the cyclic dynamics of the dominant forest rodent species, the bank vole Myodes glareolus, explain most of this. We review the relationships between Puumala hantavirus (PUUV), its host rodent, and the hantavirus disease, nephropathia epidemica (NE), in Finland. We describe the history of NE and its diagnostic research in Finland, the seasonal and multiannual cyclic dynamics of PUUV in bank voles impacting human epidemiology, and we compare our northern epidemiological patterns with those in temperate Europe. The long survival of PUUV outside the host and the life-long shedding of PUUV by the bank voles are highlighted. In humans, the infection has unique features in pathobiology but rarely long-term consequences. NE is affected by specific host genetics and risk behavior (smoking), and certain biomarkers can predict the outcome. Unlike many other hantaviruses, PUUV causes a relatively mild disease and is rarely fatal. Reinfections do not exist. Antiviral therapy is complicated by the fact that when symptoms appear, the patient already has a generalized infection. Blocking vascular leakage measures counteracting pathobiology, offer a real therapeutic approach.
Subject: bank vole
ecology
hantavirus
hemorrhagic fever with renal syndrome
nephropathia epidemica
Puumala virus
rodent
INDUCED HEMORRHAGIC-FEVER
PUUMALA VIRUS-INFECTIONS
NEPHROPATHIA-EPIDEMICA
BANK VOLES
MYODES-GLAREOLUS
RENAL SYNDROME
SOREX-ARANEUS
KIDNEY INJURY
HOST-SWITCH
DISEASE
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
viruses_13_01452_v2.pdf 291.4Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record