Associations of healthy food choices with gut microbiota profiles

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Koponen , K K , Salosensaari , A , Ruuskanen , M O , Havulinna , A S , Männistö , S , Jousilahti , P , Palmu , J , Salido , R , Sanders , K , Brennan , C , Humphrey , G C , Sanders , J G , Meric , G , Cheng , S , Inouye , M , Jain , M , Niiranen , T J , Valsta , L M , Knight , R & Salomaa , V V 2021 , ' Associations of healthy food choices with gut microbiota profiles ' , American Journal of Clinical Nutrition , vol. 114 , no. 2 , pp. 605-616 . https://doi.org/10.1093/ajcn/nqab077

Title: Associations of healthy food choices with gut microbiota profiles
Author: Koponen, Kari K.; Salosensaari, Aaro; Ruuskanen, Matti O.; Havulinna, Aki S.; Männistö, Satu; Jousilahti, Pekka; Palmu, Joonatan; Salido, Rodolfo; Sanders, Karenina; Brennan, Caitriona; Humphrey, Gregory C.; Sanders, Jon G.; Meric, Guillaume; Cheng, Susan; Inouye, Michael; Jain, Mohit; Niiranen, Teemu J.; Valsta, Liisa M.; Knight, Rob; Salomaa, Veikko V.
Other contributor: University of Helsinki, Finnish Institute for Health and Welfare
University of Helsinki, Medicum


Date: 2021-08
Language: eng
Number of pages: 12
Belongs to series: American Journal of Clinical Nutrition
ISSN: 0002-9165
DOI: https://doi.org/10.1093/ajcn/nqab077
URI: http://hdl.handle.net/10138/335341
Abstract: Background: Diet has a major influence on the human gut microbiota, which has been linked to health and disease. However, epidemiological studies on associations of a healthy diet with the microbiota utilizing a whole-diet approach are still scant. Objectives: To assess associations between healthy food choices and human gut microbiota composition, and to determine the strength of association with functional potential. Methods: This population-based study sample consisted of 4930 participants (ages 25-74; 53% women) in the FINRISK 2002 study. Intakes of recommended foods were assessed using a food propensity questionnaire, and responses were transformed into healthy food choices (HFC) scores. Microbial diversity (alpha diversity) and compositional differences (beta diversity) and their associations with the HFC score and its components were assessed using linear regression. Multiple permutational multivariate ANOVAs were run from whole-metagenome shallow shotgun-sequenced samples. Associations between specific taxa and HFC were analyzed using linear regression. Functional associations were derived from Kyoto Encyclopedia of Genes and Genomes orthologies with linear regression models. Results: Both microbial alpha diversity (beta/SD, 0.044; SE, 6.18 x 10(-5); P = 2.21 x 10(-3)) and beta diversity (R-2, 0.12; P Conclusions: Our results from a large, population-based survey confirm and extend findings of other, smaller-scale studies that plant and fiber-rich dietary choices are associated with a more diverse and compositionally distinct microbiota, and with a greater potential to produce SCFAs.
Subject: cross-sectional study
dietary score
epidemiology
healthy diet
metagenomics
microbiology
microbiota
nutrition
DIET
GENE
METABOLISM
EXPRESSION
IMPACT
CANCER
FIBER
RISK
3143 Nutrition
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