Markers of gastrointestinal permeability and dysbiosis in premenopausal women with PCOS : a case-control study

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http://hdl.handle.net/10138/335344

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Lingaiah , S , Arffman , R K , Morin-Papunen , L , Tapanainen , J S & Piltonen , T 2021 , ' Markers of gastrointestinal permeability and dysbiosis in premenopausal women with PCOS : a case-control study ' , BMJ Open , vol. 11 , no. 7 , 045324 . https://doi.org/10.1136/bmjopen-2020-045324

Title: Markers of gastrointestinal permeability and dysbiosis in premenopausal women with PCOS : a case-control study
Author: Lingaiah, Shilpa; Arffman, Riikka K.; Morin-Papunen, Laure; Tapanainen, Juha S.; Piltonen, Terhi
Contributor organization: HUS Gynecology and Obstetrics
Reproductive Disease Modeling
Department of Obstetrics and Gynecology
Clinicum
Date: 2021
Language: eng
Number of pages: 9
Belongs to series: BMJ Open
ISSN: 2044-6055
DOI: https://doi.org/10.1136/bmjopen-2020-045324
URI: http://hdl.handle.net/10138/335344
Abstract: Objectives Altered intestinal permeability and gut barrier dysfunction have been suggested to play a role in the pathogenetic mechanism of polycystic ovary syndrome (PCOS), the most common endocrine and metabolic condition in reproductive-aged women. However, data on intestinal permeability and dysbiosis of the gut microbiota in PCOS is still limited, with conflicting results. To this end, the concentrations of gastrointestinal permeability and gut dysbiosis markers were analysed in women with PCOS. Design Case-control study. Setting General community. Participants 104 women with PCOS and 203 body mass index (BMI) matched control women at age 46. Primary and secondary outcome measures Serum levels of zonulin, fatty acid-binding protein 2 (FABP2), urinary levels of indican, and hormonal and metabolic parameters. Results Serum levels of zonulin (128.0 +/- 17.0 vs 130.9 +/- 14.0 ng/mL, p=0.13) and FABP2 (1.5 +/- 0.9 vs 1.5 +/- 0.7 ng/mL, p=0.63) and urinary levels of indican (9.5 +/- 5.5 vs 8.4 +/- 4.2 mg/dL, p=0.07) were comparable in women with PCOS and controls in the whole study population. Likewise, when the study population was divided into different BMI groups as normal weight, overweight and obese, the levels of the above markers were comparable between the study groups. After BMI adjustment, zonulin levels correlated with the levels of high-sensitivity C reactive protein and homoeostasis model assessment of insulin resistance (p
Subject: gynaecology
reproductive medicine
POLYCYSTIC-OVARY-SYNDROME
OLIGOMENORRHEA AND/OR HIRSUTISM
SELF-REPORTED SYMPTOMS
ACID-BINDING PROTEIN
NORTHERN FINLAND
INSULIN-RESISTANCE
INTESTINAL PERMEABILITY
DIAGNOSTIC-CRITERIA
GUT PERMEABILITY
ZONULIN
3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion


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