PCOS Features and Steroid Profiles Among Young Adult Women with a History of Premature Adrenarche

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Tennilä , J , Jääskeläinen , J , Utriainen , P , Voutilainen , R , Häkkinen , M , Auriola , S , Morin-Papunen , L & Liimatta , J 2021 , ' PCOS Features and Steroid Profiles Among Young Adult Women with a History of Premature Adrenarche ' , Journal of Clinical Endocrinology and Metabolism , vol. 106 , no. 9 , pp. E3335-E3345 . https://doi.org/10.1210/clinem/dgab385

Title: PCOS Features and Steroid Profiles Among Young Adult Women with a History of Premature Adrenarche
Author: Tennilä, Jussi; Jääskeläinen, Jarmo; Utriainen, Pauliina; Voutilainen, Raimo; Häkkinen, Merja; Auriola, Seppo; Morin-Papunen, Laure; Liimatta, Jani
Contributor organization: HUS Children and Adolescents
Children's Hospital
CAMM - Research Program for Clinical and Molecular Metabolism
Date: 2021-09
Language: eng
Number of pages: 11
Belongs to series: Journal of Clinical Endocrinology and Metabolism
ISSN: 0021-972X
DOI: https://doi.org/10.1210/clinem/dgab385
URI: http://hdl.handle.net/10138/335413
Abstract: Context: Premature adrenarche (PA) may increase the risk for polycystic ovary syndrome (PCOS). Objective: To study features of PCOS in young adult women with a history of PA. Methods: Thirty PA and 42 control females were followed from prepuberty to young adulthood (median age 18.1 years).The main outcome measures were ovarian function, the use of contraceptives, and clinical and biochemical indicators of hyperandrogenism. Results: We found no differences in the use of hormonal contraceptives (50 vs 50%, PA vs controls, respectively; P> .999), indication for using contraceptives (P= .193), or in the history of oligo- (17 vs 26%, P= .392) and amenorrhea (0 vs 0%, P> .999). Among women not using hormonal contraceptives, those with a history of PA had a higher prevalence of hirsutism (27 vs 0%, P= .023) but not acne (87 vs 67%, P= .252). Steroid profiles were broadly comparable between the groups, but PA women had lower sex hormone-binding globulin (SHBG) concentrations (30.1 vs 62.4 nmol/L, P< .001) resulting in higher free androgen index (3.94 vs 2.14, P< .001). The difference in SHBG levels persisted through body mass index adjustment. SHBG correlated negatively with the homeostasis model assessment for insulin resistance (r -0.498, P= .003). Anti-Mullerian hormone concentrations were comparable between the groups (39.3 vs 32.1 pmol/L, P= .619). Conclusion: PA was not associated with evident ovarian dysfunction in young adult women. However, women with a history of PA had decreased SHBG levels and thus, increased bioavailability of circulating androgens.
Subject: Adrenarche
polycystic ovary syndrome
dehydroepiandrosterone sulfate
sex hormone-binding globulin
ovarian function
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion

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