The expression and prognostic relevance of programmed cell death protein 1 in tongue squamous cell carcinoma

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Tervo , S , Seppala , M , Rautiainen , M , Huhtala , H , Salo , T , Al-Samadi , A , Kuopio , T , Ahtiainen , M , Tommola , S , Paavonen , T & Toppila-Salmi , S 2020 , ' The expression and prognostic relevance of programmed cell death protein 1 in tongue squamous cell carcinoma ' , APMIS : Acta pathologica, microbiologica et immunologica Scandinavica , vol. 128 , no. 12 , pp. 626-636 . https://doi.org/10.1111/apm.13084

Title: The expression and prognostic relevance of programmed cell death protein 1 in tongue squamous cell carcinoma
Author: Tervo, Sanni; Seppala, Miia; Rautiainen, Markus; Huhtala, Heini; Salo, Tuula; Al-Samadi, Ahmed; Kuopio, Teijo; Ahtiainen, Maarit; Tommola, Satu; Paavonen, Timo; Toppila-Salmi, Sanna
Contributor: University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, HUSLAB
University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, HUS Inflammation Center
Date: 2020-12
Language: eng
Number of pages: 11
Belongs to series: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica
ISSN: 0903-4641
URI: http://hdl.handle.net/10138/335432
Abstract: Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor which plays an important role in a patient's immune responses to microbial and cancer antigens. It is expressed in tumor-infiltrating lymphocytes (TILs) with many different malignancies. The aim of the study was to evaluate PD-1 expression and its prognostic value in tongue cancer. The data of tongue squamous cell carcinoma (TSCC) patients (N = 81) treated in Tampere University Hospital between 1999 and 2013 were used. Control data consisted of patients with non-malignant tongue mucous membrane lesions (N = 48). The formalin-fixed paraffin-embedded samples were stained immunohistochemically and scanned via digital microscope. The staining of PD-1 was examined semi-quantitatively. The density and intensity of PD-1 + cells were significantly higher in TSCC than in control samples. The expression of PD-1 correlated with better survival. The expression of PD-1 could be a potential prognostic marker in TSCC. Further research using larger sample size is needed.
Subject: Programmed cell death protein 1 (PD-1)
tongue squamous cell carcinoma
prognosis
immunohistochemistry
molecular marker
LIGAND 1 PD-L1
T-CELLS
HUMAN-PAPILLOMAVIRUS
POOR-PROGNOSIS
CANCER
NECK
SURVIVAL
EPIDEMIOLOGY
LYMPHOCYTES
DISSECTION
3111 Biomedicine
11832 Microbiology and virology
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