Diagnostic Criteria for Terrien Marginal Degeneration: Nordic Terrien Degeneration Study

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Ruutila , M , Fagerholm , P , Lagali , N , Hjortdal , J , Bram , T , Moilanen , J & Kivela , TT 2021 , ' Diagnostic Criteria for Terrien Marginal Degeneration: Nordic Terrien Degeneration Study ' , Cornea , vol. 40 , no. 2 , pp. 133-141 . https://doi.org/10.1097/ICO.0000000000002427

Title: Diagnostic Criteria for Terrien Marginal Degeneration: Nordic Terrien Degeneration Study
Author: Ruutila, M; Fagerholm, P; Lagali, N; Hjortdal, J; Bram, T; Moilanen, J; Kivela, TT
Other contributor: University of Helsinki, Doctoral Programme in Clinical Research
University of Helsinki, HUS Head and Neck Center




Date: 2021-02
Language: eng
Number of pages: 9
Belongs to series: Cornea
ISSN: 0277-3740
DOI: https://doi.org/10.1097/ICO.0000000000002427
URI: http://hdl.handle.net/10138/335463
Abstract: Purpose: To refine the diagnostic criteria for Terrien marginal degeneration (TMD) based on experience in 3 Nordic countries. Methods: This is a retrospective, multicenter, hospital-based cross-sectional study of 49 eyes of 29 white patients in tertiary referral centers in Finland, Sweden, and Denmark from 1998 to January 2018. The median follow-up was 3 years. Symptoms, best corrected visual acuity, astigmatism, corneal thickness, curvature and cavities, stage, and progression were analyzed. Results: TMD was diagnosed equally likely between 15 and 86 years of age (median, 47 years). Twenty patients (69%) had bilateral disease, and 62% were men. Seventeen patients (59%) had symptoms including blurred vision and ocular surface disease symptoms without inflammatory signs. Eight patients (28%) had slightly reduced corneal sensitivity. Median best corrected visual acuity was 20/25 (range, 20/16-20/200) and astigmatism was 2.6 diopters (D) (range, 0-10) with a mean progression of 0.41 D per year (range, 0-5.4). Age and astigmatism were not correlated. All eyes had peripheral vascularization, lipid deposits, and hyperreflectivity throughout thinned peripheral stroma and its anterior edge. The thinning progressed in 15 patients (52%). Of 26 patients, 8 (31%) had single or confluent paralimbal intrastromal cavities, most commonly superiorly. By Suveges classification, the stage was 2 (92%) or 3 (8%). Minimum corneal thickness and corneal curvature were loosely associated, leading to different stages in Wang classification in 34 eyes (69%). Conclusions: TMD is defined by peripheral corneal thinning, superficial neovascularization, lipid deposition at the leading edge, absence of ulceration and inflammation, and frequently cavitation. The most sensitive way to follow its progression is anterior segment optical coherence tomography.
Subject: Terrien marginal degeneration
peripheral corneal thinning
lipid
neovascularization
cavities
LIPID KERATOPATHY
CORNEAL HYDROPS
CROSS-LINKING
MICROSCOPY
3125 Otorhinolaryngology, ophthalmology
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