Angiogenic Effects and Crosstalk of Adipose-Derived Mesenchymal Stem/Stromal Cells and Their Extracellular Vesicles with Endothelial Cells

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Rautiainen , S , Laaksonen , T & Koivuniemi , R 2021 , ' Angiogenic Effects and Crosstalk of Adipose-Derived Mesenchymal Stem/Stromal Cells and Their Extracellular Vesicles with Endothelial Cells ' , International Journal of Molecular Sciences , vol. 22 , no. 19 , 10890 . https://doi.org/10.3390/ijms221910890

Title: Angiogenic Effects and Crosstalk of Adipose-Derived Mesenchymal Stem/Stromal Cells and Their Extracellular Vesicles with Endothelial Cells
Author: Rautiainen, Swarna; Laaksonen, Timo; Koivuniemi, Raili
Other contributor: University of Helsinki, Division of Pharmaceutical Biosciences
University of Helsinki, Division of Pharmaceutical Biosciences


Date: 2021-10-01
Language: eng
Number of pages: 33
Belongs to series: International Journal of Molecular Sciences
ISSN: 1661-6596
DOI: https://doi.org/10.3390/ijms221910890
URI: http://hdl.handle.net/10138/335475
Abstract: Adipose‐derived mesenchymal stem/stromal cells (ASCs) are an adult stem cell population able to self‐renew and differentiate into numerous cell lineages. ASCs provide a promising future for therapeutic angiogenesis due to their ability to promote blood vessel formation. Specifically, their ability to differentiate into endothelial cells (ECs) and pericyte‐like cells and to secrete angiogenesis‐promoting growth factors and extracellular vesicles (EVs) makes them an ideal option in cell therapy and in regenerative medicine in conditions including tissue ischemia. In recent angiogenesis research, ASCs have often been co‐cultured with an endothelial cell (EC) type in order to form mature vessel‐like networks in specific culture conditions. In this review, we introduce co‐culture systems and co‐transplantation studies between ASCs and ECs. In co‐cultures, the cells communicate via direct cell–cell contact or via paracrine signaling. Most often, ASCs are found in the perivascular niche lining the vessels, where they stabilize the vascular structures and express common pericyte surface proteins. In co‐cultures, ASCs modulate endothelial cells and induce angiogenesis by promoting tube formation, partly via secretion of EVs. In vivo co-transplantation of ASCs and ECs showed improved formation of functional vessels over a single cell type transplantation. Adipose tissue as a cell source for both mesenchymal stem cells and ECs for co‐transplantation serves as a prominent option for therapeutic angiogenesis and blood perfusion in vivo.
Subject: 317 Pharmacy
221 Nano-technology
1182 Biochemistry, cell and molecular biology
3111 Biomedicine
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