Negative interaction of fatty liver and hypertension on cardiovascular mortality in non-diabetic men : 34 years of follow-up

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Setti , M O , Voutilainen , A , Tajik , B , Niskanen , L & Tuomainen , T-P 2021 , ' Negative interaction of fatty liver and hypertension on cardiovascular mortality in non-diabetic men : 34 years of follow-up ' , Scandinavian Journal of Gastroenterology , vol. 56 , no. 9 , pp. 1096-1102 . https://doi.org/10.1080/00365521.2021.1951836

Title: Negative interaction of fatty liver and hypertension on cardiovascular mortality in non-diabetic men : 34 years of follow-up
Author: Setti, Mounir Ould; Voutilainen, Ari; Tajik, Behnam; Niskanen, Leo; Tuomainen, Tomi-Pekka
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Date: 2021-09-02
Language: eng
Number of pages: 7
Belongs to series: Scandinavian Journal of Gastroenterology
ISSN: 0036-5521
DOI: https://doi.org/10.1080/00365521.2021.1951836
URI: http://hdl.handle.net/10138/335631
Abstract: Background and objectives Fatty liver disease (FLD) and hypertension are separately associated with cardiovascular (CV) mortality. The two conditions are related in multiple ways. This work aimed to study the joint effect and interaction of FLD and hypertension in respect to overall and CV mortality. Methods The population-based cohort, Kuopio Ischaemic Disease Risk Factor Study, followed 1569 middle-aged non-diabetic Finnish men for 34 years. Considering adjustment for age, body mass index, smoking and alcohol consumption, separate and combined effects of FLD and hypertension and their interaction at the multiplicative and additive scales regarding all-cause and CV death were assessed using Cox proportional hazards models. Results FLD and hypertension coexisted in 8.54% of the men (n = 134). FLD and hypertension associated, independently and combined, with an increased hazard of all-cause and CV deaths. Non-CV mortality associated with FLD, but not with hypertension. We found a negative interaction between FLD and hypertension regarding the hazard of all-cause (relative excess risk due to interaction (RERI), -0.97; 95% confidence interval (CI), -1.65 to -0.28) and CV mortality (RERI, -1.74; 95% CI, -2.98 to -0.5). The interaction was also found on a multiplicative scale. Conclusions We found evidence of a negative interaction between FLD and hypertension in respect to CV mortality. We thus recommend adjusting for FLD or hypertension when studying the effect of the other condition on mortality or CV diseases in middle-aged men.
Subject: Mortality
cardiovascular disease
hypertension
heart disease risk factors
fatty liver
non-alcoholic fatty liver disease
NONALCOHOLIC STEATOHEPATITIS
MYOCARDIAL-INFARCTION
BLOOD-PRESSURE
DISEASE
RISK
POPULATION
3121 General medicine, internal medicine and other clinical medicine
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