Negative interaction of fatty liver and hypertension on cardiovascular mortality in non-diabetic men : 34 years of follow-up

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dc.contributor.author Setti, Mounir Ould
dc.contributor.author Voutilainen, Ari
dc.contributor.author Tajik, Behnam
dc.contributor.author Niskanen, Leo
dc.contributor.author Tuomainen, Tomi-Pekka
dc.date.accessioned 2021-10-25T08:06:01Z
dc.date.available 2021-10-25T08:06:01Z
dc.date.issued 2021-09-02
dc.identifier.citation Setti , M O , Voutilainen , A , Tajik , B , Niskanen , L & Tuomainen , T-P 2021 , ' Negative interaction of fatty liver and hypertension on cardiovascular mortality in non-diabetic men : 34 years of follow-up ' , Scandinavian Journal of Gastroenterology , vol. 56 , no. 9 , pp. 1096-1102 . https://doi.org/10.1080/00365521.2021.1951836
dc.identifier.other PURE: 169760801
dc.identifier.other PURE UUID: fda6ebcf-f9b4-40d4-bfea-f6b4b93c4d57
dc.identifier.other WOS: 000682399500001
dc.identifier.uri http://hdl.handle.net/10138/335631
dc.description.abstract Background and objectives Fatty liver disease (FLD) and hypertension are separately associated with cardiovascular (CV) mortality. The two conditions are related in multiple ways. This work aimed to study the joint effect and interaction of FLD and hypertension in respect to overall and CV mortality. Methods The population-based cohort, Kuopio Ischaemic Disease Risk Factor Study, followed 1569 middle-aged non-diabetic Finnish men for 34 years. Considering adjustment for age, body mass index, smoking and alcohol consumption, separate and combined effects of FLD and hypertension and their interaction at the multiplicative and additive scales regarding all-cause and CV death were assessed using Cox proportional hazards models. Results FLD and hypertension coexisted in 8.54% of the men (n = 134). FLD and hypertension associated, independently and combined, with an increased hazard of all-cause and CV deaths. Non-CV mortality associated with FLD, but not with hypertension. We found a negative interaction between FLD and hypertension regarding the hazard of all-cause (relative excess risk due to interaction (RERI), -0.97; 95% confidence interval (CI), -1.65 to -0.28) and CV mortality (RERI, -1.74; 95% CI, -2.98 to -0.5). The interaction was also found on a multiplicative scale. Conclusions We found evidence of a negative interaction between FLD and hypertension in respect to CV mortality. We thus recommend adjusting for FLD or hypertension when studying the effect of the other condition on mortality or CV diseases in middle-aged men. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Scandinavian Journal of Gastroenterology
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Mortality
dc.subject cardiovascular disease
dc.subject hypertension
dc.subject heart disease risk factors
dc.subject fatty liver
dc.subject non-alcoholic fatty liver disease
dc.subject NONALCOHOLIC STEATOHEPATITIS
dc.subject MYOCARDIAL-INFARCTION
dc.subject BLOOD-PRESSURE
dc.subject DISEASE
dc.subject RISK
dc.subject POPULATION
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Negative interaction of fatty liver and hypertension on cardiovascular mortality in non-diabetic men : 34 years of follow-up en
dc.type Article
dc.contributor.organization HUS Abdominal Center
dc.contributor.organization Päijät-Häme Welfare Consortium
dc.contributor.organization HYKS erva
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1080/00365521.2021.1951836
dc.relation.issn 0036-5521
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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