Impulse oscillometry and free-running tests for diagnosing asthma and monitoring lung function in young children

Show full item record



Permalink

http://hdl.handle.net/10138/335671

Citation

Burman , J , Malmberg , L P , Remes , S , Jartti , T , Pelkonen , A S & Makela , M J 2021 , ' Impulse oscillometry and free-running tests for diagnosing asthma and monitoring lung function in young children ' , Annals of Allergy, Asthma, & Immunology , vol. 127 , no. 3 , pp. 326-333 . https://doi.org/10.1016/j.anai.2021.03.030

Title: Impulse oscillometry and free-running tests for diagnosing asthma and monitoring lung function in young children
Author: Burman, Janne; Malmberg, Leo Pekka; Remes, Sami; Jartti, Tuomas; Pelkonen, Anna S.; Makela, Mika J.
Contributor: University of Helsinki, University of Helsinki
University of Helsinki, University of Helsinki
University of Helsinki, Department of Dermatology, Allergology and Venereology
University of Helsinki, University of Helsinki
University of Helsinki, University of Helsinki
Date: 2021-09
Language: eng
Number of pages: 8
Belongs to series: Annals of Allergy, Asthma, & Immunology
ISSN: 1081-1206
URI: http://hdl.handle.net/10138/335671
Abstract: Background: Separating individuals with viral-induced wheezing from those with asthma is challenging, and there are no guidelines for children under 6 years of age. Impulse oscillometry, however, is feasible in 4-year-old children. Objective: To explore the use of impulse oscillometry in diagnosing and monitoring asthma in young children and evaluating treatment response to inhaled corticosteroid (ICS). Methods: A total of 42 children (median age 5.3 years, range 4.0-7.9 years) with physician-diagnosed asthma and lability in oscillometry were followed for 6 months after initiation of ICS treatment. All children performed the 6-minute free-running test and impulse oscillometry at 3 time points. After the baseline, they attended a second visit when they had achieved good asthma control and a third visit approximately 60 days after the second visit. A positive ICS response was defined as having greater than 19 points in asthma control test and no hyperreactivity on the third visit. Results: In total, 38 of 42 children responded to ICS treatment. Exercise-induced increases of resistance at 5 Hz decreased after ICS treatment (61% vs 18% vs 13.5%, P < .001), and running distance during the 6-minute test was lengthened (800 m vs 850 m vs 850 m, P = .001). Significant improvements in childhood asthma control scores occurred between the baseline and subsequent visits (21 vs 24 vs 24, P < .001) and acute physicians' visits for respiratory symptoms (1, (0-6) vs 0, (0-2), P = .001). Similar profiles were observed in children without aeroallergen sensitization and among those under 5 years of age. Conclusion: Impulse oscillometry is a useful tool in diagnosing asthma and monitoring lung function in young children. (C) 2021 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc.
Subject: EXHALED NITRIC-OXIDE
BRONCHIAL HYPERRESPONSIVENESS
CHILDHOOD ASTHMA
SMALL AIRWAYS
METHACHOLINE
RESPONSES
EXERCISE
RISK
BECLOMETHASONE
FLUTICASONE
3121 General medicine, internal medicine and other clinical medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
PIIS1081120621002623.pdf 1.175Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record