Aalto-Setälä , L , Uppstu , P , Sinitsyna , P , Lindfors , N C & Hupa , L 2021 , ' Dissolution of Amorphous S53P4 Glass Scaffolds in Dynamic In Vitro Conditions ' , Materials , vol. 14 , no. 17 , 4834 . https://doi.org/10.3390/ma14174834
Title: | Dissolution of Amorphous S53P4 Glass Scaffolds in Dynamic In Vitro Conditions |
Author: | Aalto-Setälä, Laura; Uppstu, Peter; Sinitsyna, Polina; Lindfors, Nina C.; Hupa, Leena |
Contributor organization: | Clinicum HUS Musculoskeletal and Plastic Surgery |
Date: | 2021-09 |
Language: | eng |
Number of pages: | 14 |
Belongs to series: | Materials |
ISSN: | 1996-1944 |
DOI: | https://doi.org/10.3390/ma14174834 |
URI: | http://hdl.handle.net/10138/335735 |
Abstract: | The silicate-based bioactive glass S53P4 is clinically used in bone regenerative applications in granule form. However, utilization of the glass in scaffold form has been limited by the high tendency of the glass to crystallize during sintering. Here, careful optimization of sintering parameters enabled the manufacture of porous amorphous S53P4 scaffolds with a strength high enough for surgical procedures in bone applications (5 MPa). Sintering was conducted in a laboratory furnace for times ranging from 25 to 300 min at 630 degrees C, i.e., narrowly below the commencement of the crystallization. The phase composition of the scaffolds was verified with XRD, and the ion release was tested in vitro and compared with granules in continuous flow of Tris buffer and simulated body fluid (SBF). The amorphous, porous S53P4 scaffolds present the possibility of using the glass composition in a wider range of applications. |
Subject: |
bioactive glasses
glass scaffolds sintering in vitro dissolution dynamic dissolution biomaterials tissue engineering BIOACTIVE GLASS MECHANICAL-PROPERTIES BONE-INFECTIONS 45S5 CRYSTALLIZATION BEHAVIOR ANGIOGENESIS DEPOSITION IMPLANTS COATINGS 3126 Surgery, anesthesiology, intensive care, radiology 217 Medical engineering |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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