Dissolution of Amorphous S53P4 Glass Scaffolds in Dynamic In Vitro Conditions

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http://hdl.handle.net/10138/335735

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Aalto-Setälä , L , Uppstu , P , Sinitsyna , P , Lindfors , N C & Hupa , L 2021 , ' Dissolution of Amorphous S53P4 Glass Scaffolds in Dynamic In Vitro Conditions ' , Materials , vol. 14 , no. 17 , 4834 . https://doi.org/10.3390/ma14174834

Title: Dissolution of Amorphous S53P4 Glass Scaffolds in Dynamic In Vitro Conditions
Author: Aalto-Setälä, Laura; Uppstu, Peter; Sinitsyna, Polina; Lindfors, Nina C.; Hupa, Leena
Other contributor: University of Helsinki, Clinicum

Date: 2021-09
Language: eng
Number of pages: 14
Belongs to series: Materials
ISSN: 1996-1944
DOI: https://doi.org/10.3390/ma14174834
URI: http://hdl.handle.net/10138/335735
Abstract: The silicate-based bioactive glass S53P4 is clinically used in bone regenerative applications in granule form. However, utilization of the glass in scaffold form has been limited by the high tendency of the glass to crystallize during sintering. Here, careful optimization of sintering parameters enabled the manufacture of porous amorphous S53P4 scaffolds with a strength high enough for surgical procedures in bone applications (5 MPa). Sintering was conducted in a laboratory furnace for times ranging from 25 to 300 min at 630 degrees C, i.e., narrowly below the commencement of the crystallization. The phase composition of the scaffolds was verified with XRD, and the ion release was tested in vitro and compared with granules in continuous flow of Tris buffer and simulated body fluid (SBF). The amorphous, porous S53P4 scaffolds present the possibility of using the glass composition in a wider range of applications.
Subject: bioactive glasses
glass scaffolds
sintering
in vitro dissolution
dynamic dissolution
biomaterials
tissue engineering
BIOACTIVE GLASS
MECHANICAL-PROPERTIES
BONE-INFECTIONS
45S5
CRYSTALLIZATION
BEHAVIOR
ANGIOGENESIS
DEPOSITION
IMPLANTS
COATINGS
3126 Surgery, anesthesiology, intensive care, radiology
217 Medical engineering
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