Dendritic Spine Initiation in Brain Development, Learning and Diseases and Impact of BAR-Domain Proteins

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http://hdl.handle.net/10138/335752

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Khanal , P & Hotulainen , P 2021 , ' Dendritic Spine Initiation in Brain Development, Learning and Diseases and Impact of BAR-Domain Proteins ' , Cells , vol. 10 , no. 9 , 2392 . https://doi.org/10.3390/cells10092392

Title: Dendritic Spine Initiation in Brain Development, Learning and Diseases and Impact of BAR-Domain Proteins
Author: Khanal, Pushpa; Hotulainen, Pirta
Other contributor: University of Helsinki, Neuroscience Center

Date: 2021-09
Language: eng
Number of pages: 25
Belongs to series: Cells
ISSN: 2073-4409
DOI: https://doi.org/10.3390/cells10092392
URI: http://hdl.handle.net/10138/335752
Abstract: Dendritic spines are small, bulbous protrusions along neuronal dendrites where most of the excitatory synapses are located. Dendritic spine density in normal human brain increases rapidly before and after birth achieving the highest density around 2-8 years. Density decreases during adolescence, reaching a stable level in adulthood. The changes in dendritic spines are considered structural correlates for synaptic plasticity as well as the basis of experience-dependent remodeling of neuronal circuits. Alterations in spine density correspond to aberrant brain function observed in various neurodevelopmental and neuropsychiatric disorders. Dendritic spine initiation affects spine density. In this review, we discuss the importance of spine initiation in brain development, learning, and potential complications resulting from altered spine initiation in neurological diseases. Current literature shows that two Bin Amphiphysin Rvs (BAR) domain-containing proteins, MIM/Mtss1 and SrGAP3, are involved in spine initiation. We review existing literature and open databases to discuss whether other BAR-domain proteins could also take part in spine initiation. Finally, we discuss the potential molecular mechanisms on how BAR-domain proteins could regulate spine initiation.
Subject: neurons
dendritic spines
BAR-domain proteins
actin cytoskeleton
learning
psychiatric diseases
synapse
CORTICAL PYRAMIDAL NEURONS
N-WASP
MENTAL-RETARDATION
RHO-GTPASES
REMODELING CONTRIBUTES
SYSTEMS CONSOLIDATION
MEMBRANE INVAGINATION
MOLECULAR-BASIS
CELL MOTILITY
NMDA RECEPTOR
1182 Biochemistry, cell and molecular biology
3112 Neurosciences
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