Episodic memory and cortical amyloid pathology : PET study in cognitively discordant twin pairs

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http://hdl.handle.net/10138/335782

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Lindgren , N , Kaprio , J , Karjalainen , T , Ekblad , L , Helin , S , Karrasch , M , Teuho , J , Rinne , J O & Vuoksimaa , E 2021 , ' Episodic memory and cortical amyloid pathology : PET study in cognitively discordant twin pairs ' , Neurobiology of Aging , vol. 108 , pp. 122-132 . https://doi.org/10.1016/j.neurobiolaging.2021.08.016

Titel: Episodic memory and cortical amyloid pathology : PET study in cognitively discordant twin pairs
Författare: Lindgren, Noora; Kaprio, Jaakko; Karjalainen, Tomi; Ekblad, Laura; Helin, Semi; Karrasch, Mira; Teuho, Jarmo; Rinne, Juha O.; Vuoksimaa, Eero
Upphovmannens organisation: University of Helsinki
Institute for Molecular Medicine Finland
Cognitive and Brain Aging
Faculty Common Matters (Faculty of Medicine)
Datum: 2021-12
Språk: eng
Sidantal: 11
Tillhör serie: Neurobiology of Aging
ISSN: 0197-4580
DOI: https://doi.org/10.1016/j.neurobiolaging.2021.08.016
Permanenta länken (URI): http://hdl.handle.net/10138/335782
Abstrakt: We studied the association between episodic memory and cortical fibrillar β-amyloid pathology within twin pairs. Using telephone-administered cognitive screening of 1415 twin pairs in a population-based older Finnish Twin Cohort study, we identified 45 (mean [SD] age 72.9 [4.0] years, 40% women) cognitively discordant same-sex twin pairs (24 dizygotic and 21 monozygotic) without neurological or psychiatric disorders other than AD or mild cognitive impairment. In-person neuropsychological testing was conducted. Cortical amyloid was measured with carbon 11-labelled Pittsburgh compound B ([11C]PiB) positron emission tomography imaging and quantified as the average standardized uptake value ratio in cortical regions affected in AD. Larger within-twin pair differences in verbal immediate (r = -0.42) and delayed free recall (r = -0.41), and visual delayed free recall (r = -0.46) were associated with larger within-twin pair differences in [11C]PiB uptake (p's < 0.01). Correlations were not significantly different in dizygotic and monozygotic pairs suggesting that the episodic memory-cortical amyloid relationship is not confounded by genetic effects. However, larger samples are needed to draw more definitive conclusions.
Beskrivning: Publisher Copyright: © 2021 The Authors
Subject: 3112 Neurosciences
Amyloid
Episodic memory
Positron emission tomography
Twins
ALZHEIMERS-DISEASE
Referentgranskad: Ja
Licens: cc_by
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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