Episodic memory and cortical amyloid pathology : PET study in cognitively discordant twin pairs

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dc.contributor.author Lindgren, Noora
dc.contributor.author Kaprio, Jaakko
dc.contributor.author Karjalainen, Tomi
dc.contributor.author Ekblad, Laura
dc.contributor.author Helin, Semi
dc.contributor.author Karrasch, Mira
dc.contributor.author Teuho, Jarmo
dc.contributor.author Rinne, Juha O.
dc.contributor.author Vuoksimaa, Eero
dc.date.accessioned 2021-10-28T09:36:03Z
dc.date.available 2021-10-28T09:36:03Z
dc.date.issued 2021-12
dc.identifier.citation Lindgren , N , Kaprio , J , Karjalainen , T , Ekblad , L , Helin , S , Karrasch , M , Teuho , J , Rinne , J O & Vuoksimaa , E 2021 , ' Episodic memory and cortical amyloid pathology : PET study in cognitively discordant twin pairs ' , Neurobiology of Aging , vol. 108 , pp. 122-132 . https://doi.org/10.1016/j.neurobiolaging.2021.08.016
dc.identifier.other PURE: 169852684
dc.identifier.other PURE UUID: de33479e-d3a0-4b53-843c-2157af706d9b
dc.identifier.other Scopus: 85117089624
dc.identifier.other ORCID: /0000-0002-6534-3667/work/102235359
dc.identifier.other WOS: 000709732200001
dc.identifier.uri http://hdl.handle.net/10138/335782
dc.description Publisher Copyright: © 2021 The Authors
dc.description.abstract We studied the association between episodic memory and cortical fibrillar β-amyloid pathology within twin pairs. Using telephone-administered cognitive screening of 1415 twin pairs in a population-based older Finnish Twin Cohort study, we identified 45 (mean [SD] age 72.9 [4.0] years, 40% women) cognitively discordant same-sex twin pairs (24 dizygotic and 21 monozygotic) without neurological or psychiatric disorders other than AD or mild cognitive impairment. In-person neuropsychological testing was conducted. Cortical amyloid was measured with carbon 11-labelled Pittsburgh compound B ([11C]PiB) positron emission tomography imaging and quantified as the average standardized uptake value ratio in cortical regions affected in AD. Larger within-twin pair differences in verbal immediate (r = -0.42) and delayed free recall (r = -0.41), and visual delayed free recall (r = -0.46) were associated with larger within-twin pair differences in [11C]PiB uptake (p's < 0.01). Correlations were not significantly different in dizygotic and monozygotic pairs suggesting that the episodic memory-cortical amyloid relationship is not confounded by genetic effects. However, larger samples are needed to draw more definitive conclusions. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Neurobiology of Aging
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3112 Neurosciences
dc.subject Amyloid
dc.subject Episodic memory
dc.subject Positron emission tomography
dc.subject Twins
dc.title Episodic memory and cortical amyloid pathology : PET study in cognitively discordant twin pairs en
dc.type Article
dc.contributor.organization University of Helsinki
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Cognitive and Brain Aging
dc.contributor.organization Faculty Common Matters (Faculty of Medicine)
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.neurobiolaging.2021.08.016
dc.relation.issn 0197-4580
dc.rights.accesslevel openAccess
dc.type.version publishedVersion
dc.identifier.url http://www.scopus.com/inward/record.url?scp=85117089624&partnerID=8YFLogxK

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