Brown Adipose Tissue, Adiposity, and Metabolic Profile in Preschool Children

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Tint , M T , Michael , N , Sadananthan , S A , Huang , J Y , Khoo , C M , Godfrey , K M , Shek , L P C , Lek , N , Tan , K H , Yap , F , Velan , S S , Gluckman , P D , Chong , Y S , Karnani , N , Chan , S Y , Leow , M K S , Lee , K J , Lee , Y S , Hu , H H , Zhang , C , Fortier , M V & Eriksson , J G 2021 , ' Brown Adipose Tissue, Adiposity, and Metabolic Profile in Preschool Children ' , Journal of Clinical Endocrinology and Metabolism , vol. 106 , no. 10 , pp. 2901-2914 .

Title: Brown Adipose Tissue, Adiposity, and Metabolic Profile in Preschool Children
Author: Tint, Mya Thway; Michael, Navin; Sadananthan, Suresh Anand; Huang, Jonathan Yinhao; Khoo, Chin Meng; Godfrey, Keith M.; Shek, Lynette Pei Chi; Lek, Ngee; Tan, Kok Hian; Yap, Fabian; Velan, S. Sendhil; Gluckman, Peter D.; Chong, Yap Seng; Karnani, Neerja; Chan, Shiao Yng; Leow, Melvin Khee Shing; Lee, Kuan Jin; Lee, Yung Seng; Hu, Houchun Harry; Zhang, Cuilin; Fortier, Marielle V.; Eriksson, Johan G.
Contributor organization: Clinicum
Department of General Practice and Primary Health Care
Date: 2021-10-01
Language: eng
Number of pages: 14
Belongs to series: Journal of Clinical Endocrinology and Metabolism
ISSN: 0021-972X
Abstract: Context: An inverse relationship between brown adipose tissue (BAT) and obesity has previously been reported in older children and adults but is unknown in young children. Objective: We investigated the influence of BAT in thermoneutral condition on adiposity and metabolic profile in Asian preschool children. Design, Setting, and Participants: A total of 198 children aged 4.5 years from a prospective birth cohort study, Growing Up in Singapore Towards Healthy Outcomes (GUSTO) were successfully studied with water-fat magnetic resonance imaging of the supraclavicular and axillary fat depot (FDSA). Regions within FDSA with fat-signal-fraction between 20% and 80% were considered BAT, and percentage BAT (%BAT; 100∗BAT volume/ FDSA volume) was calculated. Main Outcome Measures: Abdominal adipose tissue compartment volumes, ectopic fat in the soleus muscle and liver, fatty liver index, metabolic syndrome scores, and markers of insulin sensitivity. Results: A 1% unit increase in %BAT was associated with lower body mass index, difference (95% CI), -0.08 (-0.10, -0.06) kg/m2 and smaller abdominal adipose tissue compartment volumes. Ethnicity and sex modified these associations. In addition, each unit increase in %BAT was associated with lower ectopic fat at 4.5 years in the liver, -0.008% (-0.013%, -0.003%); soleus muscle, -0.003% (-0.006%, -0.001%) of water content and lower fatty liver index at 6 years. Conclusions: Higher %BAT is associated with a more favorable metabolic profile. BAT may thus play a role in the pathophysiology of obesity and related metabolic disorders. The observed ethnic and sex differences imply that the protective effect of BAT may vary among different groups.
Description: Publisher Copyright: © 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.
Subject: adiposity
brown fat
metabolic profile
preschool children
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion

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