Occurrence of sinonasal intestinal‐type adenocarcinoma and non‐intestinal‐type adenocarcinoma in two countries with different patterns of wood dust exposure

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Leivo , I , Holmila , R , Luce , D , Steiniche , T , Dictor , M , Heikkilä , P , Husgafvel‐pursiainen , K & Wolff , H 2021 , ' Occurrence of sinonasal intestinal‐type adenocarcinoma and non‐intestinal‐type adenocarcinoma in two countries with different patterns of wood dust exposure ' , Cancers , vol. 13 , no. 20 , 5245 . https://doi.org/10.3390/cancers13205245

Title: Occurrence of sinonasal intestinal‐type adenocarcinoma and non‐intestinal‐type adenocarcinoma in two countries with different patterns of wood dust exposure
Author: Leivo, Ilmo; Holmila, Reetta; Luce, Danièle; Steiniche, Torben; Dictor, Michael; Heikkilä, Pirjo; Husgafvel‐pursiainen, Kirsti; Wolff, Henrik
Other contributor: University of Helsinki, University of Turku
University of Helsinki, Medicum


Date: 2021-10-01
Language: eng
Number of pages: 11
Belongs to series: Cancers
ISSN: 2072-6694
DOI: https://doi.org/10.3390/cancers13205245
URI: http://hdl.handle.net/10138/335830
Abstract: Sinonasal intestinal‐type adenocarcinoma is strongly associated with hardwood dust ex-posure. Non‐intestinal‐type adenocarcinoma is a rarer and less well‐known subtype considered not to be related with wood dust exposure. We determined the relative numbers of these two tumor types in 56 sinonasal adenocarcinoma patients in France and Finland, relating them with carefully assessed wood dust exposure histories. Diagnostic workup including immunohistochemistry for the intestinal markers CDX2 and CK20 indicated that the proportions of the two tumors differed significantly between France and Finland. In Finnish samples non‐intestinal adenocarcinomas were more common than intestinal‐type adenocarcinomas (12 non‐intestinal vs. nine intestinal), while in the French samples the reverse was true (six non‐intestinal vs. 29 intestinal). Such remarkably dis-similar occurrence of these tumors in France and Finland presumably reflects different pathogenetic circumstances in the two countries, and perhaps their different patterns of wood dust exposure. In France the main source of wood dust is from hardwoods. In Finland it is derived from softwoods. This is the first systematic comparison of the occurrence of intestinal‐type adenocarcinoma and non-intestinal‐type adenocarcinoma in two countries with different wood usage. It appears to be the first systematic study on differences in wood dust exposure between intestinal‐type adenocarci-noma and non‐intestinal‐type adenocarcinoma.
Subject: Immunohistochemistry
Sinonasal adenocarcinoma
Sinonasal intestinal‐type adenocarcinoma
Sinonasal non‐intestinal‐type adenocarcinoma
Wood dust
3122 Cancers
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