Phosphate Concentrations and Modifying Factors in Healthy Children from 12 to 24 Months of Age

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Koljonen , L , Enlund-Cerullo , M , Hauta-Alus , H , Holmlund-Suila , E , Valkama , S , Rosendahl , J , Andersson , S , Pekkinen , M & Mäkitie , O 2021 , ' Phosphate Concentrations and Modifying Factors in Healthy Children from 12 to 24 Months of Age ' , Journal of Clinical Endocrinology and Metabolism , vol. 106 , no. 10 , pp. 2865-2875 .

Title: Phosphate Concentrations and Modifying Factors in Healthy Children from 12 to 24 Months of Age
Author: Koljonen, Laura; Enlund-Cerullo, Maria; Hauta-Alus, Helena; Holmlund-Suila, Elisa; Valkama, Saara; Rosendahl, Jenni; Andersson, Sture; Pekkinen, Minna; Mäkitie, Outi
Contributor organization: CAMM - Research Program for Clinical and Molecular Metabolism
Research Programs Unit
University of Helsinki
Children's Hospital
HUS Children and Adolescents
Lastentautien yksikkö
Date: 2021-10-01
Language: eng
Number of pages: 11
Belongs to series: Journal of Clinical Endocrinology and Metabolism
ISSN: 0021-972X
Abstract: Context: Phosphate homeostasis and its modifiers in early childhood are inadequately characterized. Objective: To determine physiological plasma phosphate concentration and modifying factors in healthy infants at 12 to 24 months of age. Design: This study included 525 healthy infants (53% girls), who participated in a randomized vitamin D intervention trial and received daily vitamin D3 supplementation of either 10 or 30 μg from age 2 weeks to 24 months. Biochemical parameters were measured at 12 and 24 months. Dietary phosphate intake was determined at 12 months. Main Outcome Measures: Plasma phosphate concentrations at 12 and 24 months of age. Results: Mean (SD) phosphate concentration decreased from 12 months (1.9±0.15 mmol/L) to 24 months (1.6±0.17 mmol/L) of age (P<0.001 for repeated measurements). When adjusted by covariates, such as body size, creatinine, serum 25-hydroxyvitamin D, intact and C-terminal fibroblast growth factor 23, mean plasma phosphate was higher in boys than girls during follow-up (P=0.019). Phosphate concentrations were similar in the vitamin D intervention groups (P>0.472 for all). Plasma iron was associated positively with plasma phosphate at both time points (B, 0.006 and 0.005; 95% CI, 0.004-0.009 and 0.002-0.008; P<0.001 at both time points, respectively). At 24 months of age, the main modifier of phosphate concentration was plasma creatinine (B, 0.007; 95% CI 0.003-0.011, P<0.001). Conclusion: Plasma phosphate concentration decreased from age 12 to 24 months. In infants and toddlers, the strongest plasma phosphate modifiers were sex, iron, and creatinine, whereas vitamin D supplementation did not modify phosphate concentrations.
Description: Publisher Copyright: © 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.
Subject: 3121 General medicine, internal medicine and other clinical medicine
clinical trial
mineral homeostasis
vitamin D
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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