Multidisciplinary Oncovascular Surgery is Safe and Effective in the Treatment of Intra-abdominal and Retroperitoneal Sarcomas : A Retrospective Single Centre Cohort Study and a Comprehensive Literature Review

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Pysyväisosoite

http://hdl.handle.net/10138/335865

Lähdeviite

Homsy , P , Blomqvist , C , Heiskanen , I , Vikatmaa , L , Tukiainen , E , Numminen , K , Sampo , M , Leppäniemi , A , Albäck , A , Kantonen , I & Vikatmaa , P 2020 , ' Multidisciplinary Oncovascular Surgery is Safe and Effective in the Treatment of Intra-abdominal and Retroperitoneal Sarcomas : A Retrospective Single Centre Cohort Study and a Comprehensive Literature Review ' , European Journal of Vascular and Endovascular Surgery , vol. 60 , no. 5 , pp. 752-763 . https://doi.org/10.1016/j.ejvs.2020.05.029

Julkaisun nimi: Multidisciplinary Oncovascular Surgery is Safe and Effective in the Treatment of Intra-abdominal and Retroperitoneal Sarcomas : A Retrospective Single Centre Cohort Study and a Comprehensive Literature Review
Tekijä: Homsy, Pauliina; Blomqvist, Carl; Heiskanen, Ilkka; Vikatmaa, Leena; Tukiainen, Erkki; Numminen, Kirsti; Sampo, Mika; Leppäniemi, Ari; Albäck, Anders; Kantonen, Ilkka; Vikatmaa, Pirkka
Tekijän organisaatio: HUS Musculoskeletal and Plastic Surgery
Plastiikkakirurgian yksikkö
University of Helsinki
Helsinki University Hospital Area
HUS Comprehensive Cancer Center
Department of Oncology
Clinicum
HUS Abdominal Center
II kirurgian klinikka
HUS Perioperative, Intensive Care and Pain Medicine
Department of Diagnostics and Therapeutics
Anestesiologian yksikkö
Department of Surgery
HUS Medical Imaging Center
Department of Pathology
Verisuonikirurgian yksikkö
Päiväys: 2020-11
Kieli: eng
Sivumäärä: 12
Kuuluu julkaisusarjaan: European Journal of Vascular and Endovascular Surgery
ISSN: 1078-5884
DOI-tunniste: https://doi.org/10.1016/j.ejvs.2020.05.029
URI: http://hdl.handle.net/10138/335865
Tiivistelmä: Objective: Radical excision of retroperitoneal or intra-abdominal soft tissue sarcomas may necessitate vessel resection and reconstruction. The aim of this study was to assess surgical results of retroperitoneal or intra-abdominal sarcomas involving major blood vessels. Methods: This was a retrospective single centre cohort study and a comprehensive review of literature. Patients with retroperitoneal or intra-abdominal sarcomas treated by the oncovascular team in Helsinki University Hospital from 2010 to 2018 were reviewed for vascular and oncological outcomes. A comprehensive literature review of vascular reconstructions in patients with retroperitoneal sarcoma was performed. Results: Vascular reconstruction was performed in 17 patients, 11 of whom required arterial reconstructions. Sixteen of the operations were sarcoma resections; the post-operative diagnosis for one patient was thrombosis instead of the presumed recurrent leiomyosarcoma. Early graft thrombosis occurred in two venous and one arterial reconstruction. Late thrombosis was detected in three (18%). The median follow up was 27 (range 0-82) months. Of the patients with sarcoma resections 5 (31%) died of sarcoma and further 4 (25%) developed local recurrence or new distant metastases. The comprehensive review of literature identified 37 articles with 110 patients, 89 of whom had inferior vena cava reconstruction only. Eight arterial reconstructions were described. Late graft thrombosis occurred in 14%. The follow up was 0-181 months, during which 57% remained disease free and 7% died of sarcoma. Conclusion: Vascular reconstructions enable radical resection of retroperitoneal and intra-abdominal sarcomas in patients with advanced disease. The complex operations are associated with an acceptable rate of serious perioperative complications and symptomatic thrombosis of the repaired vessel is rare. However, further studies are needed to assess the performance of the vascular reconstructions in the long term.
Avainsanat: Oncovascular surgery
Retroperitoneum
Sarcoma
Vascular reconstruction
INFERIOR VENA-CAVA
SOFT-TISSUE SARCOMA
PROSTHETIC REPLACEMENT
EN-BLOC
VASCULAR RECONSTRUCTION
PRIMARY LEIOMYOSARCOMA
SURGICAL-MANAGEMENT
CASE SERIES
RESECTION
GRAFT
3126 Surgery, anesthesiology, intensive care, radiology
Vertaisarvioitu: Kyllä
Tekijänoikeustiedot: cc_by_nc_nd
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: acceptedVersion


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