Multidisciplinary Oncovascular Surgery is Safe and Effective in the Treatment of Intra-abdominal and Retroperitoneal Sarcomas : A Retrospective Single Centre Cohort Study and a Comprehensive Literature Review

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dc.contributor.author Homsy, Pauliina
dc.contributor.author Blomqvist, Carl
dc.contributor.author Heiskanen, Ilkka
dc.contributor.author Vikatmaa, Leena
dc.contributor.author Tukiainen, Erkki
dc.contributor.author Numminen, Kirsti
dc.contributor.author Sampo, Mika
dc.contributor.author Leppäniemi, Ari
dc.contributor.author Albäck, Anders
dc.contributor.author Kantonen, Ilkka
dc.contributor.author Vikatmaa, Pirkka
dc.date.accessioned 2021-10-31T23:06:59Z
dc.date.available 2021-12-18T03:46:07Z
dc.date.issued 2020-11
dc.identifier.citation Homsy , P , Blomqvist , C , Heiskanen , I , Vikatmaa , L , Tukiainen , E , Numminen , K , Sampo , M , Leppäniemi , A , Albäck , A , Kantonen , I & Vikatmaa , P 2020 , ' Multidisciplinary Oncovascular Surgery is Safe and Effective in the Treatment of Intra-abdominal and Retroperitoneal Sarcomas : A Retrospective Single Centre Cohort Study and a Comprehensive Literature Review ' , European Journal of Vascular and Endovascular Surgery , vol. 60 , no. 5 , pp. 752-763 . https://doi.org/10.1016/j.ejvs.2020.05.029
dc.identifier.other PURE: 156524297
dc.identifier.other PURE UUID: e37dab6b-9331-4606-a8cf-eb60436c783a
dc.identifier.other WOS: 000587341100024
dc.identifier.uri http://hdl.handle.net/10138/335865
dc.description.abstract Objective: Radical excision of retroperitoneal or intra-abdominal soft tissue sarcomas may necessitate vessel resection and reconstruction. The aim of this study was to assess surgical results of retroperitoneal or intra-abdominal sarcomas involving major blood vessels. Methods: This was a retrospective single centre cohort study and a comprehensive review of literature. Patients with retroperitoneal or intra-abdominal sarcomas treated by the oncovascular team in Helsinki University Hospital from 2010 to 2018 were reviewed for vascular and oncological outcomes. A comprehensive literature review of vascular reconstructions in patients with retroperitoneal sarcoma was performed. Results: Vascular reconstruction was performed in 17 patients, 11 of whom required arterial reconstructions. Sixteen of the operations were sarcoma resections; the post-operative diagnosis for one patient was thrombosis instead of the presumed recurrent leiomyosarcoma. Early graft thrombosis occurred in two venous and one arterial reconstruction. Late thrombosis was detected in three (18%). The median follow up was 27 (range 0-82) months. Of the patients with sarcoma resections 5 (31%) died of sarcoma and further 4 (25%) developed local recurrence or new distant metastases. The comprehensive review of literature identified 37 articles with 110 patients, 89 of whom had inferior vena cava reconstruction only. Eight arterial reconstructions were described. Late graft thrombosis occurred in 14%. The follow up was 0-181 months, during which 57% remained disease free and 7% died of sarcoma. Conclusion: Vascular reconstructions enable radical resection of retroperitoneal and intra-abdominal sarcomas in patients with advanced disease. The complex operations are associated with an acceptable rate of serious perioperative complications and symptomatic thrombosis of the repaired vessel is rare. However, further studies are needed to assess the performance of the vascular reconstructions in the long term. en
dc.format.extent 12
dc.language.iso eng
dc.relation.ispartof European Journal of Vascular and Endovascular Surgery
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Oncovascular surgery
dc.subject Retroperitoneum
dc.subject Sarcoma
dc.subject Vascular reconstruction
dc.subject INFERIOR VENA-CAVA
dc.subject SOFT-TISSUE SARCOMA
dc.subject PROSTHETIC REPLACEMENT
dc.subject EN-BLOC
dc.subject VASCULAR RECONSTRUCTION
dc.subject PRIMARY LEIOMYOSARCOMA
dc.subject SURGICAL-MANAGEMENT
dc.subject CASE SERIES
dc.subject RESECTION
dc.subject GRAFT
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.title Multidisciplinary Oncovascular Surgery is Safe and Effective in the Treatment of Intra-abdominal and Retroperitoneal Sarcomas : A Retrospective Single Centre Cohort Study and a Comprehensive Literature Review en
dc.type Review Article
dc.contributor.organization HUS Musculoskeletal and Plastic Surgery
dc.contributor.organization Plastiikkakirurgian yksikkö
dc.contributor.organization University of Helsinki
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization HUS Comprehensive Cancer Center
dc.contributor.organization Department of Oncology
dc.contributor.organization Clinicum
dc.contributor.organization HUS Abdominal Center
dc.contributor.organization II kirurgian klinikka
dc.contributor.organization HUS Perioperative, Intensive Care and Pain Medicine
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization Anestesiologian yksikkö
dc.contributor.organization Department of Surgery
dc.contributor.organization HUS Medical Imaging Center
dc.contributor.organization Department of Pathology
dc.contributor.organization Verisuonikirurgian yksikkö
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.ejvs.2020.05.029
dc.relation.issn 1078-5884
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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