Sentinel lymph node biopsies in early stage oral and oropharyngeal carcinoma : a retrospective single-centre experience

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http://hdl.handle.net/10138/335868

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Marttila , E , Keski-Säntti , H , Hagström , J , Snäll , J & Wilkman , T 2020 , ' Sentinel lymph node biopsies in early stage oral and oropharyngeal carcinoma : a retrospective single-centre experience ' , British Journal of Oral and Maxillofacial Surgery , vol. 58 , no. 9 , pp. 1078-1083 . https://doi.org/10.1016/j.bjoms.2020.05.022

Title: Sentinel lymph node biopsies in early stage oral and oropharyngeal carcinoma : a retrospective single-centre experience
Author: Marttila, E.; Keski-Säntti, H.; Hagström, J.; Snäll, J.; Wilkman, T.
Contributor: University of Helsinki, HUS Head and Neck Center
University of Helsinki, HUS Head and Neck Center
University of Helsinki, HUS Head and Neck Center
University of Helsinki, HUS Head and Neck Center
University of Helsinki, HUS Head and Neck Center
Date: 2020-11
Language: eng
Number of pages: 6
Belongs to series: British Journal of Oral and Maxillofacial Surgery
ISSN: 0266-4356
URI: http://hdl.handle.net/10138/335868
Abstract: The aim of this retrospective study was to analyse a consecutive series of patients with oral and oropharyngeal carcinoma who had had sentinel lymph node biopsy (SLNB) at our hospital during 2008-2017. A total of 70 patients with clinically and radiologically confirmed primary oral (n = 67) or oropharyngeal (n = 3) carcinoma, with no signs of metastatic lymph nodes preoperatively (clinically N0) were included. Patients' clinical and personal data, characteristics of the tumours, sentinel lymph node (SLN) status and outcomes were recorded. Eight patients had invaded SLN. Two patients with clear sentinel lymph node biopsies had recurrences in the cervical lymph nodes with no new primary tumour as origin. The negative predictive value (NPV) and sensitivity for SLNB were 97% and 80%, respectively. The depth of invasion was an individual predictor for cervical lymph node metastasis (p = 0.043). Single photo emission computed tomography (SPECT) detected fewer SLN in patients with invaded lymph nodes than in patients with clear lymph nodes (p = 0.018). Our data support the use of SLNB as a minimally invasive method for staging the cervical lymph nodes among patients with cN0 oral and oropharyngeal carcinoma. Our results further confirm that greater depth of invasion is associated with cervical lymph node metastases. (c) 2020 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
Subject: Sentinel lymph node biopsy
cervical lymph node
oral carcinoma
oropharyngeal carcinoma
neck dissection
invasion
metastasis
SQUAMOUS-CELL CARCINOMA
NECK DISSECTION
CANCER
TONGUE
HEAD
METASTASIS
CAVITY
FLOOR
313 Dentistry
3126 Surgery, anesthesiology, intensive care, radiology
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