Low Expression of Stanniocalcin 1 (STC-1) Protein Is Associated With Poor Clinicopathologic Features of Endometrial Cancer

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dc.contributor.author Khatun, Masuma
dc.contributor.author Urpilainen, Elina
dc.contributor.author Ahtikoski, Anne
dc.contributor.author Arffman, Riikka K.
dc.contributor.author Pasanen, Annukka
dc.contributor.author Puistola, Ulla
dc.contributor.author Tapanainen, Juha S.
dc.contributor.author Andersson, Leif C.
dc.contributor.author Butzow, Ralf
dc.contributor.author Loukovaara, Mikko
dc.contributor.author Piltonen, Terhi T.
dc.date.accessioned 2021-11-01T07:11:02Z
dc.date.available 2021-11-01T07:11:02Z
dc.date.issued 2021-09-28
dc.identifier.citation Khatun , M , Urpilainen , E , Ahtikoski , A , Arffman , R K , Pasanen , A , Puistola , U , Tapanainen , J S , Andersson , L C , Butzow , R , Loukovaara , M & Piltonen , T T 2021 , ' Low Expression of Stanniocalcin 1 (STC-1) Protein Is Associated With Poor Clinicopathologic Features of Endometrial Cancer ' , Pathology and Oncology Research , vol. 27 , 1609936 . https://doi.org/10.3389/pore.2021.1609936
dc.identifier.other PURE: 169959913
dc.identifier.other PURE UUID: 357be901-70fb-412e-8401-201addeba448
dc.identifier.other Scopus: 85117122771
dc.identifier.other WOS: 000705929600001
dc.identifier.uri http://hdl.handle.net/10138/335887
dc.description Publisher Copyright: © Copyright © 2021 Khatun, Urpilainen, Ahtikoski, Arffman, Pasanen, Puistola, Tapanainen, Andersson, Butzow, Loukovaara and Piltonen.
dc.description.abstract Stanniocalcin-1 (STC-1) is a glycoprotein hormone involved in diverse biological processes, including regulation of calcium phosphate homeostasis, cell proliferation, apoptosis, inflammation, oxidative stress responses, and cancer development. The role of STC-1 in endometrial cancer (EC) is yet to be elucidated. In this study, we investigated the protein expression pattern of STC-1 in a tissue microarray (TMA) cohort of hysterectomy specimens from 832 patients with EC. We then evaluated the prognostic value of STC-1 expression regarding the clinicopathologic features and patients survival over a period of 140 months. Our results revealed that in EC tissue samples, STC-1 is mainly localized in the endometrial epithelium, although some expression was also observed in the stroma. Decreased STC-1 expression was associated with factors relating to a worse prognosis, such as grade 3 endometrioid tumors (p = 0.030), deep myometrial invasion (p = 0.003), lymphovascular space invasion (p = 0.050), and large tumor size (p = 0.001). Moreover, STC-1 expression was decreased in tumors obtained from obese women (p = 0.014) and in women with diabetes mellitus type 2 (DMT2; p = 0.001). Interestingly, the data also showed an association between DNA mismatch repair (MMR) deficiency and weak STC-1 expression, specifically in the endometrial epithelium (p = 0.048). No association was observed between STC-1 expression and disease-specific survival. As STC-1 expression was particularly low in cases with obesity and DMT2 in the TMA cohort, we also evaluated the correlation between metformin use and STC-1 expression in an additional EC cohort that only included women with DMT2 (n = 111). The analysis showed no difference in STC-1 expression in either the epithelium or the stroma in women undergoing metformin therapy compared to metformin non-users. Overall, our data may suggest a favorable role for STC-1 in EC behavior; however, further studies are required to elucidate the detailed mechanism and possible applications to cancer treatment. en
dc.format.extent 9
dc.language.iso eng
dc.relation.ispartof Pathology and Oncology Research
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3111 Biomedicine
dc.subject disease-specific survival
dc.subject endometrioid carcinoma
dc.subject metformin
dc.subject stanniocalcin-1
dc.subject type 2 diabetes mellitus
dc.subject uterine cancer
dc.subject METFORMIN
dc.subject CELLS
dc.subject BIOMARKER
dc.subject INVASION
dc.subject CARCINOMA
dc.subject 3123 Gynaecology and paediatrics
dc.title Low Expression of Stanniocalcin 1 (STC-1) Protein Is Associated With Poor Clinicopathologic Features of Endometrial Cancer en
dc.type Article
dc.contributor.organization Department of Pathology
dc.contributor.organization University of Helsinki
dc.contributor.organization HUSLAB
dc.contributor.organization HUS Gynecology and Obstetrics
dc.contributor.organization Reproductive Disease Modeling
dc.contributor.organization Department of Obstetrics and Gynecology
dc.contributor.organization Clinicum
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization Medicum
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3389/pore.2021.1609936
dc.relation.issn 1219-4956
dc.rights.accesslevel openAccess
dc.type.version publishedVersion
dc.identifier.url http://www.scopus.com/inward/record.url?scp=85117122771&partnerID=8YFLogxK

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