dc.contributor.author |
Khatun, Masuma |
|
dc.contributor.author |
Urpilainen, Elina |
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dc.contributor.author |
Ahtikoski, Anne |
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dc.contributor.author |
Arffman, Riikka K. |
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dc.contributor.author |
Pasanen, Annukka |
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dc.contributor.author |
Puistola, Ulla |
|
dc.contributor.author |
Tapanainen, Juha S. |
|
dc.contributor.author |
Andersson, Leif C. |
|
dc.contributor.author |
Butzow, Ralf |
|
dc.contributor.author |
Loukovaara, Mikko |
|
dc.contributor.author |
Piltonen, Terhi T. |
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dc.date.accessioned |
2021-11-01T07:11:02Z |
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dc.date.available |
2021-11-01T07:11:02Z |
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dc.date.issued |
2021-09-28 |
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dc.identifier.citation |
Khatun , M , Urpilainen , E , Ahtikoski , A , Arffman , R K , Pasanen , A , Puistola , U , Tapanainen , J S , Andersson , L C , Butzow , R , Loukovaara , M & Piltonen , T T 2021 , ' Low Expression of Stanniocalcin 1 (STC-1) Protein Is Associated With Poor Clinicopathologic Features of Endometrial Cancer ' , Pathology and Oncology Research , vol. 27 , 1609936 . https://doi.org/10.3389/pore.2021.1609936 |
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dc.identifier.other |
PURE: 169959913 |
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dc.identifier.other |
PURE UUID: 357be901-70fb-412e-8401-201addeba448 |
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dc.identifier.other |
Scopus: 85117122771 |
|
dc.identifier.other |
WOS: 000705929600001 |
|
dc.identifier.uri |
http://hdl.handle.net/10138/335887 |
|
dc.description |
Publisher Copyright: © Copyright © 2021 Khatun, Urpilainen, Ahtikoski, Arffman, Pasanen, Puistola, Tapanainen, Andersson, Butzow, Loukovaara and Piltonen. |
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dc.description.abstract |
Stanniocalcin-1 (STC-1) is a glycoprotein hormone involved in diverse biological processes, including regulation of calcium phosphate homeostasis, cell proliferation, apoptosis, inflammation, oxidative stress responses, and cancer development. The role of STC-1 in endometrial cancer (EC) is yet to be elucidated. In this study, we investigated the protein expression pattern of STC-1 in a tissue microarray (TMA) cohort of hysterectomy specimens from 832 patients with EC. We then evaluated the prognostic value of STC-1 expression regarding the clinicopathologic features and patients survival over a period of 140 months. Our results revealed that in EC tissue samples, STC-1 is mainly localized in the endometrial epithelium, although some expression was also observed in the stroma. Decreased STC-1 expression was associated with factors relating to a worse prognosis, such as grade 3 endometrioid tumors (p = 0.030), deep myometrial invasion (p = 0.003), lymphovascular space invasion (p = 0.050), and large tumor size (p = 0.001). Moreover, STC-1 expression was decreased in tumors obtained from obese women (p = 0.014) and in women with diabetes mellitus type 2 (DMT2; p = 0.001). Interestingly, the data also showed an association between DNA mismatch repair (MMR) deficiency and weak STC-1 expression, specifically in the endometrial epithelium (p = 0.048). No association was observed between STC-1 expression and disease-specific survival. As STC-1 expression was particularly low in cases with obesity and DMT2 in the TMA cohort, we also evaluated the correlation between metformin use and STC-1 expression in an additional EC cohort that only included women with DMT2 (n = 111). The analysis showed no difference in STC-1 expression in either the epithelium or the stroma in women undergoing metformin therapy compared to metformin non-users. Overall, our data may suggest a favorable role for STC-1 in EC behavior; however, further studies are required to elucidate the detailed mechanism and possible applications to cancer treatment. |
en |
dc.format.extent |
9 |
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dc.language.iso |
eng |
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dc.relation.ispartof |
Pathology and Oncology Research |
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dc.rights |
cc_by |
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dc.rights.uri |
info:eu-repo/semantics/openAccess |
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dc.subject |
3111 Biomedicine |
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dc.subject |
disease-specific survival |
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dc.subject |
endometrioid carcinoma |
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dc.subject |
metformin |
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dc.subject |
stanniocalcin-1 |
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dc.subject |
type 2 diabetes mellitus |
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dc.subject |
uterine cancer |
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dc.subject |
METFORMIN |
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dc.subject |
CELLS |
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dc.subject |
BIOMARKER |
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dc.subject |
RENAL ISCHEMIA/REPERFUSION INJURY |
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dc.subject |
INVASION |
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dc.subject |
ELEVATED EXPRESSION |
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dc.subject |
GENE-EXPRESSION |
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dc.subject |
CARCINOMA |
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dc.subject |
3123 Gynaecology and paediatrics |
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dc.title |
Low Expression of Stanniocalcin 1 (STC-1) Protein Is Associated With Poor Clinicopathologic Features of Endometrial Cancer |
en |
dc.type |
Article |
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dc.contributor.organization |
Department of Pathology |
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dc.contributor.organization |
University of Helsinki |
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dc.contributor.organization |
HUSLAB |
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dc.contributor.organization |
HUS Gynecology and Obstetrics |
|
dc.contributor.organization |
Reproductive Disease Modeling |
|
dc.contributor.organization |
Department of Obstetrics and Gynecology |
|
dc.contributor.organization |
Clinicum |
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dc.contributor.organization |
Helsinki University Hospital Area |
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dc.contributor.organization |
Medicum |
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dc.description.reviewstatus |
Peer reviewed |
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dc.relation.doi |
https://doi.org/10.3389/pore.2021.1609936 |
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dc.relation.issn |
1219-4956 |
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dc.rights.accesslevel |
openAccess |
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dc.type.version |
publishedVersion |
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dc.identifier.url |
http://www.scopus.com/inward/record.url?scp=85117122771&partnerID=8YFLogxK |
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