Xylitol production from plant biomass by Aspergillus niger through metabolic engineering

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http://hdl.handle.net/10138/335922

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Meng , J , Chroumpi , T , Mäkelä , M & de Vries , R 2022 , ' Xylitol production from plant biomass by Aspergillus niger through metabolic engineering ' , Bioresource Technology , vol. 344 , 126199 . https://doi.org/10.1016/j.biortech.2021.126199

Title: Xylitol production from plant biomass by Aspergillus niger through metabolic engineering
Author: Meng, Jiali; Chroumpi, Tania; Mäkelä, Miia; de Vries, Ronald
Contributor organization: Department of Microbiology
Helsinki Institute of Sustainability Science (HELSUS)
Date: 2022-01
Language: eng
Number of pages: 9
Belongs to series: Bioresource Technology
ISSN: 0960-8524
DOI: https://doi.org/10.1016/j.biortech.2021.126199
URI: http://hdl.handle.net/10138/335922
Abstract: Xylitol is widely used in the food and pharmaceutical industries as a valuable commodity product. Biotechnological production of xylitol from lignocellulosic biomass by microorganisms is a promising alternative option to chemical synthesis or bioconversion from D-xylose. In this study, four metabolic mutants of Aspergillus niger were constructed and evaluated for xylitol accumulation from D-xylose and lignocellulosic biomass. All mutants had strongly increased xylitol production from pure D-xylose, beechwood xylan, wheat bran and cotton seed hulls compared to the reference strain, but not from several other feed stocks. The triple mutant Delta ladA Delta xdhA Delta sdhA showed the best performance in xylitol production from wheat bran and cotton seed hulls. This study demonstrated the large potential of A. niger for xylitol production directly from lignocellulosic biomass by metabolic engineering.
Subject: 11831 Plant biology
Aspergillus niger
Pentose catabolic pathway
Xylitol production
Lignocellulosic biomass
Metabolic engineering
SACCHAROMYCES-CEREVISIAE
D-XYLOSE
FERMENTATION
EXPRESSION
GLUCOSE
XLNR
REDUCTASE
PROTEIN
STRAIN
GENES
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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