Serum and Urinary Osteocalcin in Healthy 7-to 19-Year-Old Finnish Children and Adolescents

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dc.contributor.author Paldanius, Päivi M.
dc.contributor.author Ivaska, Kaisa K.
dc.contributor.author Mäkitie, Outi
dc.contributor.author Viljakainen, Heli
dc.date.accessioned 2021-11-01T17:47:02Z
dc.date.available 2021-11-01T17:47:02Z
dc.date.issued 2021-08-24
dc.identifier.citation Paldanius , P M , Ivaska , K K , Mäkitie , O & Viljakainen , H 2021 , ' Serum and Urinary Osteocalcin in Healthy 7-to 19-Year-Old Finnish Children and Adolescents ' , Frontiers in pediatrics , vol. 9 . https://doi.org/10.3389/fped.2021.610227
dc.identifier.other PURE: 169969780
dc.identifier.other PURE UUID: f6db67fd-6ee3-415c-a72d-1d2a0eff9bf6
dc.identifier.other WOS: 000696557200001
dc.identifier.other ORCID: /0000-0002-7486-3437/work/102448498
dc.identifier.uri http://hdl.handle.net/10138/335924
dc.description.abstract Children and adolescents have high bone turnover marker (BTM) levels due to high growth velocity and rapid bone turnover. Pediatric normative values for BTMs reflecting bone formation and resorption are vital for timely assessment of healthy bone turnover, investigating skeletal diseases, or monitoring treatment outcomes. Optimally, clinically feasible measurement protocols for BTMs would be validated and measurable in both urine and serum. We aimed to (a) establish sex- and age-specific reference intervals for urinary and serum total and carboxylated osteocalcin (OC) in 7- to 19-year-old healthy Finnish children and adolescents (n = 172), (b) validate these against standardized serum and urinary BTMs, and (c) assess the impact of anthropometry, pubertal status, and body composition on the OC values. All OC values in addition to other BTMs increased with puberty and correlated with pubertal growth, which occurred and declined earlier in girls than in boys. The mean serum total and carboxylated OC and urinary OC values and percentiles for sex-specific age categories and pubertal stages were established. Correlation between serum and urinary OC was weak, especially in younger boys, but improved with increasing age. The independent determinants for OC varied, the urinary OC being the most robust while age, height, weight, and plasma parathyroid hormone (PTH) influenced serum total and carboxylated OC values. Body composition parameters had no influence on any of the OC values. In children and adolescents, circulating and urinary OC reflect more accurately growth status than bone mineral density (BMD) or body composition. Thus, validity of OC, similar to other BTMs, as a single marker of bone turnover, remains limited. Yet, serum and urinary OC similarly to other BTMs provide a valuable supplementary tool when assessing longitudinal changes in bone health with repeat measurements, in combination with other clinically relevant parameters. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Frontiers in pediatrics
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject pediatric normative values
dc.subject bone turnover markers
dc.subject serum osteocalcin
dc.subject urinary mid-fragment osteocalcin
dc.subject sex and age-specific ranges
dc.subject BONE-MINERAL DENSITY
dc.subject BIOCHEMICAL MARKERS
dc.subject REFERENCE INTERVALS
dc.subject TURNOVER MARKERS
dc.subject BODY-COMPOSITION
dc.subject REFERENCE CURVES
dc.subject METABOLISM
dc.subject GROWTH
dc.subject AGE
dc.subject FRACTURES
dc.subject 3123 Gynaecology and paediatrics
dc.title Serum and Urinary Osteocalcin in Healthy 7-to 19-Year-Old Finnish Children and Adolescents en
dc.type Article
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization Children's Hospital
dc.contributor.organization CAMM - Research Program for Clinical and Molecular Metabolism
dc.contributor.organization Research Programs Unit
dc.contributor.organization Clinicum
dc.contributor.organization Lastentautien yksikkö
dc.contributor.organization Department of Food and Nutrition
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3389/fped.2021.610227
dc.relation.issn 2296-2360
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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