Long-term health-related quality of life of breast cancer survivors remains impaired compared to the age-matched general population especially in young women. Results from the prospective controlled BREX exercise study

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Roine , E , Sintonen , H , Kellokumpu-Lehtinen , P-L , Penttinen , H , Utriainen , M , Vehmanen , L , Huovinen , R , Kautiainen , H , Nikander , R , Blomqvist , C , Hakamies-Blomqvist , L & Saarto , T 2021 , ' Long-term health-related quality of life of breast cancer survivors remains impaired compared to the age-matched general population especially in young women. Results from the prospective controlled BREX exercise study ' , Breast , vol. 59 , pp. 110-116 . https://doi.org/10.1016/j.breast.2021.06.012

Titel: Long-term health-related quality of life of breast cancer survivors remains impaired compared to the age-matched general population especially in young women. Results from the prospective controlled BREX exercise study
Författare: Roine, Eija; Sintonen, Harri; Kellokumpu-Lehtinen, Pirkko-Liisa; Penttinen, Heidi; Utriainen, Meri; Vehmanen, Leena; Huovinen, Riikka; Kautiainen, Hannu; Nikander, Riku; Blomqvist, Carl; Hakamies-Blomqvist, Liisa; Saarto, Tiina
Upphovmannens organisation: HUS Comprehensive Cancer Center
Department of Oncology
Clinicum
Harri Sintonen Research Group
Department of Public Health
Medicum
Datum: 2021-10
Språk: eng
Sidantal: 7
Tillhör serie: Breast
ISSN: 0960-9776
DOI: https://doi.org/10.1016/j.breast.2021.06.012
Permanenta länken (URI): http://hdl.handle.net/10138/335931
Abstrakt: Objective: To investigate long-term health-related quality of life (HRQoL) changes over time in younger compared to older disease-free breast cancer survivors who participated in a prospective randomized exercise trial. Methods: Survivors (aged 35-68 years) were randomized to a 12-month exercise trial after adjuvant treatment and followed up for ten years. HRQoL was assessed with the generic 15D instrument during follow-up and the younger (baseline age < 50) and older (age >50) survivors' HRQoL was compared to that of the age-matched general female population (n = 892). The analysis included 342 survivors. Results: The decline of HRQoL compared to the population was steeper and recovery slower in the younger survivors (p for interaction < 0.001). The impairment was also larger among the younger sur-vivors (p = 0.027) whose mean HRQoL deteriorated for three years after treatment and started to slowly improve thereafter but still remained below the population level after ten years (difference-0.017, 95% CI:-0.031 to-0.004). The older survivors' mean HRQoL gradually approached the population level during the first five years but also remained below it at ten years (difference-0.019, 95% CI:-0.031 to-0.0 07). The largest differences were on the dimensions of sleeping and sexual activity, on which both age groups remained below the population level throughout the follow-up. Conclusions: HRQoL developed differently in younger and older survivors both regarding the most affected dimensions of HRQoL and the timing of the changes during follow-up. HRQoL of both age groups remained below the population level even ten years after treatment. (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Subject: Breast neoplasms
Cancer survivors
Exercise
Follow-up studies
Health-related quality of life
Utility
PHYSICAL PERFORMANCE
MENOPAUSE
IMPACT
SYMPTOMS
3122 Cancers
Referentgranskad: Ja
Licens: cc_by_nc_nd
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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