Long-term health-related quality of life of breast cancer survivors remains impaired compared to the age-matched general population especially in young women. Results from the prospective controlled BREX exercise study

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dc.contributor.author Roine, Eija
dc.contributor.author Sintonen, Harri
dc.contributor.author Kellokumpu-Lehtinen, Pirkko-Liisa
dc.contributor.author Penttinen, Heidi
dc.contributor.author Utriainen, Meri
dc.contributor.author Vehmanen, Leena
dc.contributor.author Huovinen, Riikka
dc.contributor.author Kautiainen, Hannu
dc.contributor.author Nikander, Riku
dc.contributor.author Blomqvist, Carl
dc.contributor.author Hakamies-Blomqvist, Liisa
dc.contributor.author Saarto, Tiina
dc.date.accessioned 2021-11-01T19:19:04Z
dc.date.available 2021-11-01T19:19:04Z
dc.date.issued 2021-10
dc.identifier.citation Roine , E , Sintonen , H , Kellokumpu-Lehtinen , P-L , Penttinen , H , Utriainen , M , Vehmanen , L , Huovinen , R , Kautiainen , H , Nikander , R , Blomqvist , C , Hakamies-Blomqvist , L & Saarto , T 2021 , ' Long-term health-related quality of life of breast cancer survivors remains impaired compared to the age-matched general population especially in young women. Results from the prospective controlled BREX exercise study ' , Breast , vol. 59 , pp. 110-116 . https://doi.org/10.1016/j.breast.2021.06.012
dc.identifier.other PURE: 169972780
dc.identifier.other PURE UUID: eca9af20-c570-424a-8bf0-bc5a89bccb3f
dc.identifier.other WOS: 000696705600015
dc.identifier.uri http://hdl.handle.net/10138/335931
dc.description.abstract Objective: To investigate long-term health-related quality of life (HRQoL) changes over time in younger compared to older disease-free breast cancer survivors who participated in a prospective randomized exercise trial. Methods: Survivors (aged 35-68 years) were randomized to a 12-month exercise trial after adjuvant treatment and followed up for ten years. HRQoL was assessed with the generic 15D instrument during follow-up and the younger (baseline age < 50) and older (age >50) survivors' HRQoL was compared to that of the age-matched general female population (n = 892). The analysis included 342 survivors. Results: The decline of HRQoL compared to the population was steeper and recovery slower in the younger survivors (p for interaction < 0.001). The impairment was also larger among the younger sur-vivors (p = 0.027) whose mean HRQoL deteriorated for three years after treatment and started to slowly improve thereafter but still remained below the population level after ten years (difference-0.017, 95% CI:-0.031 to-0.004). The older survivors' mean HRQoL gradually approached the population level during the first five years but also remained below it at ten years (difference-0.019, 95% CI:-0.031 to-0.0 07). The largest differences were on the dimensions of sleeping and sexual activity, on which both age groups remained below the population level throughout the follow-up. Conclusions: HRQoL developed differently in younger and older survivors both regarding the most affected dimensions of HRQoL and the timing of the changes during follow-up. HRQoL of both age groups remained below the population level even ten years after treatment. (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Breast
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Breast neoplasms
dc.subject Cancer survivors
dc.subject Exercise
dc.subject Follow-up studies
dc.subject Health-related quality of life
dc.subject Utility
dc.subject PHYSICAL PERFORMANCE
dc.subject MENOPAUSE
dc.subject IMPACT
dc.subject SYMPTOMS
dc.subject 3122 Cancers
dc.title Long-term health-related quality of life of breast cancer survivors remains impaired compared to the age-matched general population especially in young women. Results from the prospective controlled BREX exercise study en
dc.type Article
dc.contributor.organization HUS Comprehensive Cancer Center
dc.contributor.organization Department of Oncology
dc.contributor.organization Clinicum
dc.contributor.organization Harri Sintonen Research Group
dc.contributor.organization Department of Public Health
dc.contributor.organization Medicum
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.breast.2021.06.012
dc.relation.issn 0960-9776
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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