Childhood Exposure to Parental Smoking and Midlife Cognitive Function The Young Finns Study

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Rovio , S P , Pihlman , J , Pahkala , K , Juonala , M , Magnussen , C G , Pitkänen , N , Ahola-Olli , A , Salo , P , Kähönen , M , Hutri-Kähönen , N , Lehtimäki , T , Jokinen , E , Laitinen , T , Taittonen , L , Tossavainen , P , Viikari , J S A & Raitakari , O T 2020 , ' Childhood Exposure to Parental Smoking and Midlife Cognitive Function The Young Finns Study ' , American Journal of Epidemiology , vol. 189 , no. 11 , pp. 1280-1291 . https://doi.org/10.1093/aje/kwaa052

Title: Childhood Exposure to Parental Smoking and Midlife Cognitive Function The Young Finns Study
Author: Rovio, Suvi P.; Pihlman, Jukka; Pahkala, Katja; Juonala, Markus; Magnussen, Costan G.; Pitkänen, Niina; Ahola-Olli, Ari; Salo, Pia; Kähönen, Mika; Hutri-Kähönen, Nina; Lehtimäki, Terho; Jokinen, Eero; Laitinen, Tomi; Taittonen, Leena; Tossavainen, Päivi; Viikari, Jorma S. A.; Raitakari, Olli T.
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, HUS Children and Adolescents
Date: 2020-11
Language: eng
Number of pages: 12
Belongs to series: American Journal of Epidemiology
ISSN: 0002-9262
URI: http://hdl.handle.net/10138/335936
Abstract: We studied whether exposure to parental smoking in childhood/adolescence is associated with midlife cognitive function, leveraging data from the Cardiovascular Risk in Young Finns Study. A population-based cohort of 3,596 children/adolescents aged 3-18 years was followed between 1980 and 2011. In 2011, cognitive testing was performed on 2,026 participants aged 34-49 years using computerized testing. Measures of secondhand smoke exposure in childhood/adolescence consisted of parental self-reports of smoking and participants' serum cotinine levels. Participants were classified into 3 exposure groups: 1) no exposure (nonsmoking parents, cotinine 1.0 ng/mL). Analyses adjusted for sex, age, family socioeconomic status, polygenic risk score for cognitive function, adolescent/adult smoking, blood pressure, and serum total cholesterol level. Compared with the nonexposed, participants exposed to nonhygienic parental smoking were at higher risk of poor (lowest quartile) midlife episodic memory and associative learning (relative risk (RR) = 1.38, 95% confidence interval (CI): 1.08, 1.75), and a weak association was found for short-term and spatial working memory (RR = 1.25, 95% CI: 0.98, 1.58). Associations for those exposed to hygienic parental smoking were nonsignificant (episodic memory and associative learning: RR = 1.19, 95% CI: 0.92, 1.54; short-term and spatial working memory: RR = 1.10, 95% CI: 0.85, 1.34). We conclude that avoiding childhood/adolescence secondhand smoke exposure promotes adulthood cognitive function.
Subject: Cambridge Neuropsychological Test Automated Battery
cognitive function
parental smoking
passive smoking
secondhand smoke
tobacco smoke
CARDIOVASCULAR RISK-FACTORS
SELF-REPORTED SMOKING
NICOTINE EXPOSURE
OXIDATIVE STRESS
SECONDHAND SMOKE
CIGARETTE-SMOKE
ADULTHOOD
COTININE
AGE
PERFORMANCE
3142 Public health care science, environmental and occupational health
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