Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial : Results of a Post-Hoc Subgroup Analysis

Show full item record



Permalink

http://hdl.handle.net/10138/335943

Citation

FINGER Study Grp , Stephen , R , Ngandu , T , Liu , Y , Peltonen , M , Antikainen , R , Kemppainen , N , Laatikainen , T , Lötjönen , J , Rinne , J , Strandberg , T , Tuomilehto , J , Vanninen , R , Soininen , H , Kivipelto , M & Solomon , A 2021 , ' Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial : Results of a Post-Hoc Subgroup Analysis ' , Journals of Gerontology. Series A: Biological Sciences and Medical Sciences , vol. 76 , no. 8 , pp. 1407-1414 . https://doi.org/10.1093/gerona/glab130

Title: Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial : Results of a Post-Hoc Subgroup Analysis
Author: FINGER Study Grp; Stephen, Ruth; Ngandu, Tiia; Liu, Yawu; Peltonen, Markku; Antikainen, Riitta; Kemppainen, Nina; Laatikainen, Tiina; Lötjönen, Jyrki; Rinne, Juha; Strandberg, Timo; Tuomilehto, Jaakko; Vanninen, Ritva; Soininen, Hilkka; Kivipelto, Miia; Solomon, Alina
Other contributor: University of Helsinki, HUS Internal Medicine and Rehabilitation
University of Helsinki, Clinicum




Date: 2021-08
Language: eng
Number of pages: 8
Belongs to series: Journals of Gerontology. Series A: Biological Sciences and Medical Sciences
ISSN: 1079-5006
DOI: https://doi.org/10.1093/gerona/glab130
URI: http://hdl.handle.net/10138/335943
Abstract: The CAIDE (Cardiovascular Risk Factors, Aging and Dementia) Risk Score is a validated tool estimating dementia risk. It was previously associated with imaging biomarkers. However, associations between dementia risk scores (including CAIDE) and dementia-related biomarkers have not been studied in the context of an intervention. This study investigated associations between change in CAIDE score and change in neuroimaging biomarkers (brain magnetic resonance imaging [MRI] and Pittsburgh Compound B-positron emission tomography [PiB-PET] measures) during the 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) (post-hoc analyses). FINGER targeted at-risk older adults, aged 60-77 years, from the general population. Participants were randomized to either multidomain intervention (diet, exercise, cognitive training, and vascular risk management) or control group (general health advice). Neuroimaging (MRI and PiB-PET) data from baseline and 2-year visits were used. A toal of 112 participants had repeated brain MRI measures (hippocampal, total gray matter, and white matter lesion volumes, and Alzheimer's disease signature cortical thickness). Repeated PiB-PET scans were available for 39 participants. Reduction in CAIDE score (indicating lower dementia risk) during the intervention was associated with less decline in hippocampus volume in the intervention group, but not the control group (Randomization group x CAIDE change interaction beta coefficient = -0.40, p = .02). Associations for other neuroimaging measures were not significant. The intervention may have benefits on hippocampal volume in individuals who succeed in improving their overall risk level as indicated by a reduction in CAIDE score. This exploratory finding requires further testing and validation in larger studies.
Subject: Dementia
Hippocampus
Prevention
Risk reduction
FINNISH GERIATRIC INTERVENTION
PREVENT COGNITIVE IMPAIRMENT
HIPPOCAMPAL VOLUME
BLOOD-PRESSURE
BRAIN ATROPHY
SERUM-LIPIDS
NEURODEGENERATION
PROGRESSION
PREDICTION
LINK
3121 General medicine, internal medicine and other clinical medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
glab130.pdf 404.5Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record