Autograft cellular composition and outcome in myeloma patients: Results of the prospective multicenter GOA study

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Turunen , A , Silvennoinen , R , Partanen , A , Valtola , J , Siitonen , T , Putkonen , M , Sankelo , M , Pyorala , M , Kuittinen , T , Penttila , K , Sikio , A , Savolainen , ER , Mantymaa , P , Pelkonen , J , Varmavuo , V & Jantunen , E 2021 , ' Autograft cellular composition and outcome in myeloma patients: Results of the prospective multicenter GOA study ' , Transfusion , vol. 61 , no. 6 , pp. 1830-1844 . https://doi.org/10.1111/trf.16424

Title: Autograft cellular composition and outcome in myeloma patients: Results of the prospective multicenter GOA study
Author: Turunen, A; Silvennoinen, R; Partanen, A; Valtola, J; Siitonen, T; Putkonen, M; Sankelo, M; Pyorala, M; Kuittinen, T; Penttila, K; Sikio, A; Savolainen, ER; Mantymaa, P; Pelkonen, J; Varmavuo, V; Jantunen, E
Contributor organization: Department of Oncology
HUS Comprehensive Cancer Center
Hematologian yksikkö
Department of Medicine
Clinicum
HYKS erva
Date: 2021-06
Language: eng
Number of pages: 15
Belongs to series: Transfusion
ISSN: 0041-1132
DOI: https://doi.org/10.1111/trf.16424
URI: http://hdl.handle.net/10138/336123
Abstract: Background Autologous stem cell transplantation (auto-SCT) is a widely used treatment option in multiple myeloma (MM) patients. The optimal graft cellular composition is not known. Study design and methods Autograft cellular composition was analyzed after freezing by flow cytometry in 127 MM patients participating in a prospective multicenter study. The impact of graft cellular composition on hematologic recovery and outcome after auto-SCT was evaluated. Results A higher graft CD34(+) cell content predicted faster platelet recovery after auto-SCT in both the short and long term. In patients with standard-risk cytogenetics, a higher graft CD34(+) count (>2.5 x 10/kg) was linked with shorter progression-free survival (PFS; 28 vs. 46 months, p = 0.04), but there was no difference in overall survival (OS) (p = 0.53). In a multivariate model, a higher graft CD34(+)CD133(+)CD38(-) (>0.065 x 10/kg, p = 0.009) and NK cell count (>2.5 x 10/kg, p = 0.026), lenalidomide maintenance and standard-risk cytogenetics predicted better PFS. In contrast, a higher CD34(+) count (>2.5 x 10/kg, p = 0.015) predicted worse PFS. A very low CD3(+) cell count ( Conclusions Autograft cellular composition may impact outcome in MM patients after auto-SCT. More studies are needed to define optimal graft composition.
Subject: 3122 Cancers
autograft cellular composition
autologous stem cell transplantation
CD34(+) cells
hematologic recovery
myeloma
NK cells
outcome
T lymphocytes
HIGH-DOSE CHEMOTHERAPY
SINGLE-CENTER EXPERIENCE
NON-HODGKIN-LYMPHOMA
MULTIPLE-MYELOMA
PERIPHERAL-BLOOD
HEMATOPOIETIC STEM
AUTOLOGOUS TRANSPLANTATION
FREE SURVIVAL
PREDICTIVE FACTORS
CD34(+) CELLS
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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