Genetic meta-analysis of twin birth weight shows high genetic correlation with singleton birth weight

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Beck , J J , Pool , R , van de Weijer , M , Chen , X , Krapohl , E , Gordon , S D , Nygaard , M , Debrabant , B , Palviainen , T , van der Zee , M D , Baselmans , B , Finnicum , C T , Yi , L , Lundstrom , S , van Beijsterveldt , T , Christiansen , L , Heikkilä , K , Kittelsrud , J , Loukola , A , Ollikainen , M , Christensen , K , Martin , N G , Plomin , R , Nivard , M , Bartels , M , Dolan , C , Willemsen , G , de Geus , E , Almqvist , C , Magnusson , P K E , Mbarek , H , Ehli , E A , Boomsma , D & Hottenga , J-J 2021 , ' Genetic meta-analysis of twin birth weight shows high genetic correlation with singleton birth weight ' , Human Molecular Genetics , vol. 30 , no. 19 , pp. 1894-1905 . https://doi.org/10.1093/hmg/ddab121

Title: Genetic meta-analysis of twin birth weight shows high genetic correlation with singleton birth weight
Author: Beck, Jeffrey J.; Pool, Rene; van de Weijer, Margot; Chen, Xu; Krapohl, Eva; Gordon, Scott D.; Nygaard, Marianne; Debrabant, Birgit; Palviainen, Teemu; van der Zee, Matthijs D.; Baselmans, Bart; Finnicum, Casey T.; Yi, Lu; Lundstrom, Sebastian; van Beijsterveldt, Toos; Christiansen, Lene; Heikkilä, Kauko; Kittelsrud, Julie; Loukola, Anu; Ollikainen, Miina; Christensen, Kaare; Martin, Nicholas G.; Plomin, Robert; Nivard, Michel; Bartels, Meike; Dolan, Conor; Willemsen, Gonneke; de Geus, Eco; Almqvist, Catarina; Magnusson, Patrik K. E.; Mbarek, Hamdi; Ehli, Erik A.; Boomsma, Dorret; Hottenga, Jouke-Jan
Contributor organization: Institute for Molecular Medicine Finland
Genetic Epidemiology
HUSLAB
Date: 2021-10-01
Language: eng
Number of pages: 12
Belongs to series: Human Molecular Genetics
ISSN: 0964-6906
DOI: https://doi.org/10.1093/hmg/ddab121
URI: http://hdl.handle.net/10138/336210
Abstract: Birth weight (BW) is an important predictor of newborn survival and health and has associations with many adult health outcomes, including cardiometabolic disorders, autoimmune diseases and mental health. On average, twins have a lower BW than singletons as a result of a different pattern of fetal growth and shorter gestational duration. Therefore, investigations into the genetics of BW often exclude data from twins, leading to a reduction in sample size and remaining ambiguities concerning the genetic contribution to BW in twins. In this study, we carried out a genome-wide association meta-analysis of BW in 42 212 twin individuals and found a positive correlation of beta values (Pearson's r = 0.66, 95% confidence interval [CI]: 0.47-0.77) with 150 previously reported genome-wide significant variants for singleton BW. We identified strong positive genetic correlations between BW in twins and numerous anthropometric traits, most notably with BW in singletons (genetic correlation [r(g)]= 0.92, 95% CI: 0.66-1.18). Genetic correlations of BW in twins with a series of health-related traits closely resembled those previously observed for BW in singletons. Polygenic scores constructed from a genome-wide association study on BW in the UK Biobank demonstrated strong predictive power in a target sample of Dutch twins and singletons. Together, our results indicate that a similar genetic architecture underlies BW in twins and singletons and that future genome-wide studies might benefit from including data from large twin registers.
Subject: CARDIOVASCULAR RISK-FACTORS
GENOME-WIDE ASSOCIATION
LD SCORE REGRESSION
BLOOD-PRESSURE
DEVELOPMENTAL ORIGINS
PERINATAL-MORTALITY
ADOLESCENT TWIN
FETAL ORIGINS
HEART-DISEASE
REGISTER
3111 Biomedicine
1184 Genetics, developmental biology, physiology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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