Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span

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Grunewald , M , Kumar , S , Sharife , H , Volinsky , E , Gileles-Hillel , A , Licht , T , Permyakova , A , Hinden , L , Azar , S , Friedmann , Y , Kupetz , P , Tzuberi , R , Anisimov , A , Alitalo , K , Horwitz , M , Leebhoff , S , Khoma , O Z , Hlushchuk , R , Djonov , V G , Abramovitch , R , Tam , J & Keshet , E 2021 , ' Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span ' , Science , vol. 373 , no. 6554 , pp. 533-+ . https://doi.org/10.1126/science.abc8479

Title: Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span
Author: Grunewald, M.; Kumar, S.; Sharife, H.; Volinsky, E.; Gileles-Hillel, A.; Licht, T.; Permyakova, A.; Hinden, L.; Azar, S.; Friedmann, Y.; Kupetz, P.; Tzuberi, R.; Anisimov, A.; Alitalo, K.; Horwitz, M.; Leebhoff, S.; Khoma, O. Z.; Hlushchuk, R.; Djonov, Valentin G; Abramovitch, R.; Tam, J.; Keshet, E.
Contributor: University of Helsinki, CAN-PRO - Translational Cancer Medicine Program
University of Helsinki, HUSLAB
Date: 2021-07-30
Language: eng
Number of pages: 56
Belongs to series: Science
ISSN: 0036-8075
URI: http://hdl.handle.net/10138/336456
Abstract: Aging is an established risk factor for vascular diseases, but vascular aging itself may contribute to the progressive deterioration of organ function. Here, we show in aged mice that vascular endothelial growth factor (VEGF) signaling insufficiency, which is caused by increased production of decoy receptors, may drive physiological aging across multiple organ systems. Increasing VEGF signaling prevented age-associated capillary loss, improved organ perfusion and function, and extended life span. Healthier aging was evidenced by favorable metabolism and body composition and amelioration of aging-associated pathologies including hepatic steatosis, sarcopenia, osteoporosis, "inflammaging" (age-related multiorgan chronic inflammation), and increased tumor burden. These results indicate that VEGF signaling insufficiency affects organ aging in mice and suggest that modulating this pathway may result in increased mammalian life span and improved overall health.
Subject: ENDOTHELIAL GROWTH-FACTOR
LONGEVITY
NEOVASCULARIZATION
MECHANISMS
INSIGHTS
PROVIDES
SYSTEM
MUSCLE
LIVER
3121 General medicine, internal medicine and other clinical medicine
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