Genomic convergence between Akkermansia muciniphila in different mammalian hosts

Show full item record



Permalink

http://hdl.handle.net/10138/336462

Citation

Geerlings , S Y , Ouwerkerk , J P , Koehorst , J J , Ritari , J , Aalvink , S , Stecher , B , Schaap , P J , Paulin , L , de Vos , W M & Belzer , C 2021 , ' Genomic convergence between Akkermansia muciniphila in different mammalian hosts ' , BMC Microbiology , vol. 21 , no. 1 , 298 . https://doi.org/10.1186/s12866-021-02360-6

Title: Genomic convergence between Akkermansia muciniphila in different mammalian hosts
Author: Geerlings, Sharon Y.; Ouwerkerk, Janneke P.; Koehorst, Jasper J.; Ritari, Jarmo; Aalvink, Steven; Stecher, Bärbel; Schaap, Peter J.; Paulin, Lars; de Vos, Willem M.; Belzer, Clara
Contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Department of Bacteriology and Immunology
Date: 2021-10-29
Language: eng
Number of pages: 13
Belongs to series: BMC Microbiology
ISSN: 1471-2180
URI: http://hdl.handle.net/10138/336462
Abstract: Background Akkermansia muciniphila is a member of the human gut microbiota where it resides in the mucus layer and uses mucin as the sole carbon, nitrogen and energy source. A. muciniphila is the only representative of the Verrucomicrobia phylum in the human gut. However, A. muciniphila 16S rRNA gene sequences have also been found in the intestines of many vertebrates. Results We detected A. muciniphila-like bacteria in the intestines of animals belonging to 15 out of 16 mammalian orders. In addition, other species belonging to the Verrucomicrobia phylum were detected in fecal samples. We isolated 10 new A. muciniphila strains from the feces of chimpanzee, siamang, mouse, pig, reindeer, horse and elephant. The physiology and genome of these strains were highly similar in comparison to the type strain A. muciniphila Muc(T). Overall, the genomes of the new strains showed high average nucleotide identity (93.9 to 99.7%). In these genomes, we detected considerable conservation of at least 75 of the 78 mucin degradation genes that were previously detected in the genome of the type strain Muc(T). Conclusions The low genomic divergence observed in the new strains may indicate that A. muciniphila favors mucosal colonization independent of the differences in hosts. In addition, the conserved mucus degradation capability points towards a similar beneficial role of the new strains in regulating host metabolic health.
Subject: Comparative genomics
Phylogenetic analysis
Gut bacteria
Beneficial microbe
Gastrointestinal-tract
RIBOSOMAL-RNA
GUT MICROBIOTA
SP NOV.
SINGLE-CELL
GEN. NOV.
ANNOTATION
DIVERSITY
EVOLUTION
11832 Microbiology and virology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
s12866_021_02360_6.pdf 2.552Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record