Hydrolyzable tannins (ellagitannins), flavonoids, pentacyclic triterpenes and their glycosides in antimycobacterial extracts of the ethnopharmacologically selected Sudanese medicinal plant Combretum hartmannianum Schweinf

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Salih , E Y A , Julkunen-Tiitto , R , Luukkanen , O , Fahmi , M K M & Fyhrquist , P 2021 , ' Hydrolyzable tannins (ellagitannins), flavonoids, pentacyclic triterpenes and their glycosides in antimycobacterial extracts of the ethnopharmacologically selected Sudanese medicinal plant Combretum hartmannianum Schweinf ' , Biomedicine & Pharmacotherapy , vol. 144 , 112264 . https://doi.org/10.1016/j.biopha.2021.112264

Title: Hydrolyzable tannins (ellagitannins), flavonoids, pentacyclic triterpenes and their glycosides in antimycobacterial extracts of the ethnopharmacologically selected Sudanese medicinal plant Combretum hartmannianum Schweinf
Author: Salih, Enass Y. A.; Julkunen-Tiitto, Riitta; Luukkanen, Olavi; Fahmi, Mustafa K. M.; Fyhrquist, Pia
Other contributor: University of Helsinki, Divisions of Faculty of Pharmacy
University of Helsinki, Department of Forest Sciences
University of Helsinki, University of Khartoum
University of Helsinki, Drug Research Program





Date: 2021-12
Language: eng
Number of pages: 18
Belongs to series: Biomedicine & Pharmacotherapy
ISSN: 0753-3322
DOI: https://doi.org/10.1016/j.biopha.2021.112264
URI: http://hdl.handle.net/10138/336493
Abstract: In Sudanese traditional medicine, decoctions, macerations, and tonics of the stem and root of Combretum hart-mannianum are used for the treatment of persistent cough, a symptom that could be related to tuberculosis (TB). To verify these traditional uses, extracts from the stem wood, stem bark, and roots of C. hartmannianum were screened for their growth inhibitory effects against Mycobacterium smegmatis ATCC 14468. Methanol Soxhlet and ethyl acetate extracts of the root gave the strongest effects (MIC 312.5 and 625 mu g/ml, respectively). HPLC-UV/DAD and UHPLC/QTOF-MS analysis of the ethyl acetate extract of the root led to the detection of 54 compounds, of which most were polyphenols and many characterized for the first time in C. hartmannianum. Among the major compounds were terflavin B and its two isomers, castalagin, corilagin, tellimagrandin I and its derivative, (S)-flavogallonic acid dilactone, punicalagin, and methyl-ellagic acid xylopyranoside. In addition, di-, tri- and tetragalloyl glucose, combregenin, terminolic acid, cordifoliside D, luteolin, and quercetin-3-O-galactoside-7-O-rhamnoside-(2 -> 1)-O-beta-D-arabinopyranoside were characterized. Luteolin gave better growth inhibition against M. smegmatis (MIC 250 mu g/ml) than corilagin, ellagic acid, and gallic acid (MIC 500-1000 mu g/ml). Our study justifies the use of C. hartmannianum in Sudanese folk medicine against prolonged cough that could be related to TB infection. This study demonstrates that C. hartmannianum should be explored further for new anti-TB drug scaffolds and antibiotic adjuvants.
Subject: Combretum hartmannianum
Traditional medicine
Tuberculosis
Ellagitannins
Flavonoids
Terpenoids
URONIC-ACID MATERIALS
MYCOBACTERIUM-TUBERCULOSIS
ANTIMICROBIAL ACTIVITY
ANTIOXIDANT ACTIVITY
QUANTITATIVE-DETERMINATION
POLYPHENOLIC COMPOUNDS
BIOACTIVE FLAVONOIDS
STRUCTURAL FEATURES
TERMINALIA-CHEBULA
FURAN GLYCOSIDES
317 Pharmacy
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