Daily Administered Dual-Light Photodynamic Therapy Provides a Sustained Antibacterial Effect on Staphylococcus aureus

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http://hdl.handle.net/10138/336529

Lähdeviite

Nikinmaa , S , Podonyi , A , Raivio , P , Meurman , J , Sorsa , T , Rantala , J , Kankuri , E , Tauriainen , T & Pätilä , T 2021 , ' Daily Administered Dual-Light Photodynamic Therapy Provides a Sustained Antibacterial Effect on Staphylococcus aureus ' , Antibiotics , vol. 10 , no. 10 , 1240 . https://doi.org/10.3390/antibiotics10101240

Julkaisun nimi: Daily Administered Dual-Light Photodynamic Therapy Provides a Sustained Antibacterial Effect on Staphylococcus aureus
Tekijä: Nikinmaa, Sakari; Podonyi, Anna; Raivio, Peter; Meurman, Jukka; Sorsa, Timo; Rantala, Juha; Kankuri, Esko; Tauriainen, Tuomas; Pätilä, Tommi
Tekijän organisaatio: HUS Heart and Lung Center
Clinicum
HUS Head and Neck Center
Department of Oral and Maxillofacial Diseases
Medicum
Department of Pharmacology
Esko Markus Kankuri / Principal Investigator
Children's Hospital
HUS Children and Adolescents
III kirurgian klinikka
Päiväys: 2021-10
Kieli: eng
Sivumäärä: 14
Kuuluu julkaisusarjaan: Antibiotics
ISSN: 2079-6382
DOI-tunniste: https://doi.org/10.3390/antibiotics10101240
URI: http://hdl.handle.net/10138/336529
Tiivistelmä: New means to reduce excessive antibiotic use are urgently needed. This study tested dual-light aPDT against Staphylococcus aureus biofilm with different relative ratios of light energy with indocyanine green. We applied single-light aPDT (810 nm aPDT, 405 aBL) or dual-light aPDT (simultaneous 810 nm aPDT and 405 nm aBL), in both cases, together with the ICG photosensitizer with constant energy of 100 or 200 J/cm(2). Single-dose light exposures were given after one-day, three-day, or six-day biofilm incubations. A repeated daily dose of identical light energy was applied during biofilm incubations for the three- and six-day biofilms. Using 100 J/cm(2) light energy against the one-day biofilm, the dual-light aPDT consisting of more than half of aBL was the most effective. On a three-day maturated biofilm, single-dose exposure to aPDT or dual-light aPDT was more effective than aBL alone. With total light energy of 200 J/cm(2), all dual-light treatments were effective. Dual-light aPDT improves the bactericidal effect on Staphylococcus aureus biofilm compared to aPDT or aBL and provides a sustained effect. An increase in the relative ratio of aBL strengthens the antibacterial effect, mainly when the treatment is repeatedly applied. Thus, the light components' energy ratio is essential with dual-light.
Avainsanat: biofilm
Staphylococcus aureus
antibacterial photodynamic therapy
405 NM
EPIDEMIOLOGY
ENDOCARDITIS
RESISTANCE
MICROBIOLOGY
PREVALENCE
BACTEREMIA
INFECTION
3111 Biomedicine
Vertaisarvioitu: Kyllä
Tekijänoikeustiedot: cc_by
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: publishedVersion


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