Daily Administered Dual-Light Photodynamic Therapy Provides a Sustained Antibacterial Effect on Staphylococcus aureus

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dc.contributor.author Nikinmaa, Sakari
dc.contributor.author Podonyi, Anna
dc.contributor.author Raivio, Peter
dc.contributor.author Meurman, Jukka
dc.contributor.author Sorsa, Timo
dc.contributor.author Rantala, Juha
dc.contributor.author Kankuri, Esko
dc.contributor.author Tauriainen, Tuomas
dc.contributor.author Pätilä, Tommi
dc.date.accessioned 2021-11-19T06:51:01Z
dc.date.available 2021-11-19T06:51:01Z
dc.date.issued 2021-10
dc.identifier.citation Nikinmaa , S , Podonyi , A , Raivio , P , Meurman , J , Sorsa , T , Rantala , J , Kankuri , E , Tauriainen , T & Pätilä , T 2021 , ' Daily Administered Dual-Light Photodynamic Therapy Provides a Sustained Antibacterial Effect on Staphylococcus aureus ' , Antibiotics , vol. 10 , no. 10 , 1240 . https://doi.org/10.3390/antibiotics10101240
dc.identifier.other PURE: 170417743
dc.identifier.other PURE UUID: d9369991-2204-49b4-afe6-12a0ae78511a
dc.identifier.other WOS: 000713645600001
dc.identifier.uri http://hdl.handle.net/10138/336529
dc.description.abstract New means to reduce excessive antibiotic use are urgently needed. This study tested dual-light aPDT against Staphylococcus aureus biofilm with different relative ratios of light energy with indocyanine green. We applied single-light aPDT (810 nm aPDT, 405 aBL) or dual-light aPDT (simultaneous 810 nm aPDT and 405 nm aBL), in both cases, together with the ICG photosensitizer with constant energy of 100 or 200 J/cm(2). Single-dose light exposures were given after one-day, three-day, or six-day biofilm incubations. A repeated daily dose of identical light energy was applied during biofilm incubations for the three- and six-day biofilms. Using 100 J/cm(2) light energy against the one-day biofilm, the dual-light aPDT consisting of more than half of aBL was the most effective. On a three-day maturated biofilm, single-dose exposure to aPDT or dual-light aPDT was more effective than aBL alone. With total light energy of 200 J/cm(2), all dual-light treatments were effective. Dual-light aPDT improves the bactericidal effect on Staphylococcus aureus biofilm compared to aPDT or aBL and provides a sustained effect. An increase in the relative ratio of aBL strengthens the antibacterial effect, mainly when the treatment is repeatedly applied. Thus, the light components' energy ratio is essential with dual-light. en
dc.format.extent 14
dc.language.iso eng
dc.relation.ispartof Antibiotics
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject biofilm
dc.subject Staphylococcus aureus
dc.subject antibacterial photodynamic therapy
dc.subject 405 NM
dc.subject EPIDEMIOLOGY
dc.subject ENDOCARDITIS
dc.subject RESISTANCE
dc.subject MICROBIOLOGY
dc.subject PREVALENCE
dc.subject BACTEREMIA
dc.subject INFECTION
dc.subject 3111 Biomedicine
dc.title Daily Administered Dual-Light Photodynamic Therapy Provides a Sustained Antibacterial Effect on Staphylococcus aureus en
dc.type Article
dc.contributor.organization HUS Heart and Lung Center
dc.contributor.organization Clinicum
dc.contributor.organization HUS Head and Neck Center
dc.contributor.organization Department of Oral and Maxillofacial Diseases
dc.contributor.organization Medicum
dc.contributor.organization Department of Pharmacology
dc.contributor.organization Esko Markus Kankuri / Principal Investigator
dc.contributor.organization Children's Hospital
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization III kirurgian klinikka
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3390/antibiotics10101240
dc.relation.issn 2079-6382
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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