Low-Dose Doxycycline Treatment Normalizes Levels of Some Salivary Metabolites Associated with Oral Microbiota in Patients with Primary Sjogren's Syndrome

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Herrala , M , Turunen , S , Hanhineva , K , Lehtonen , M , Mikkonen , J J W , Seitsalo , H , Lappalainen , R , Tjäderhane , L , Niemelä , R K , Salo , T , Myllymaa , S , Kullaa , A M & Kärkkäinen , O 2021 , ' Low-Dose Doxycycline Treatment Normalizes Levels of Some Salivary Metabolites Associated with Oral Microbiota in Patients with Primary Sjogren's Syndrome ' , Metabolites , vol. 11 , no. 9 , 595 . https://doi.org/10.3390/metabo11090595

Title: Low-Dose Doxycycline Treatment Normalizes Levels of Some Salivary Metabolites Associated with Oral Microbiota in Patients with Primary Sjogren's Syndrome
Author: Herrala, Maria; Turunen, Soile; Hanhineva, Kati; Lehtonen, Marko; Mikkonen, Jopi J. W.; Seitsalo, Hubertus; Lappalainen, Reijo; Tjäderhane, Leo; Niemelä, Raija K.; Salo, Tuula; Myllymaa, Sami; Kullaa, Arja M.; Kärkkäinen, Olli
Contributor: University of Helsinki, HUS Head and Neck Center
University of Helsinki, HUSLAB
Date: 2021-09
Language: eng
Number of pages: 13
Belongs to series: Metabolites
ISSN: 2218-1989
URI: http://hdl.handle.net/10138/336541
Abstract: Saliva is a complex oral fluid, and plays a major role in oral health. Primary Sjogren's syndrome (pSS), as an autoimmune disease that typically causes hyposalivation. In the present study, salivary metabolites were studied from stimulated saliva samples (n = 15) of female patients with pSS in a group treated with low-dose doxycycline (LDD), saliva samples (n = 10) of non-treated female patients with pSS, and saliva samples (n = 14) of healthy age-matched females as controls. Saliva samples were analyzed with liquid chromatography mass spectrometry (LC-MS) based on the non-targeted metabolomics method. The saliva metabolite profile differed between pSS patients and the healthy control (HC). In the pSS patients, the LDD treatment normalized saliva levels of several metabolites, including tyrosine glutamine dipeptide, phenylalanine isoleucine dipeptide, valine leucine dipeptide, phenylalanine, pantothenic acid (vitamin B5), urocanic acid, and salivary lipid cholesteryl palmitic acid (CE 16:0), to levels seen in the saliva samples of the HC. In conclusion, the data showed that pSS is associated with an altered saliva metabolite profile compared to the HC and that the LLD treatment normalized levels of several metabolites associated with dysbiosis of oral microbiota in pSS patients. The role of the saliva metabolome in pSS pathology needs to be further studied to clarify if saliva metabolite levels can be used to predict or monitor the progress and treatment of pSS.
Subject: saliva
Sjogren's syndrome
metabolomics
hyposalivation
doxycycline
METABOLOMICS
LIPIDS
1182 Biochemistry, cell and molecular biology
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