High Oxygen Does Not Increase Reperfusion Injury Assessed with Lipid Peroxidation Biomarkers after Cardiac Arrest : A Post Hoc Analysis of the COMACARE Trial

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Humaloja , J , Vento , M , Kuligowski , J , Andersson , S , Pineiro-Ramos , J D , Sanchez-Illana , A , Litonius , E , Jakkula , P , Hästbacka , J , Bendel , S , Tiainen , M , Reinikainen , M & Skrifvars , M B 2021 , ' High Oxygen Does Not Increase Reperfusion Injury Assessed with Lipid Peroxidation Biomarkers after Cardiac Arrest : A Post Hoc Analysis of the COMACARE Trial ' , Journal of clinical medicine , vol. 10 , no. 18 , 4226 . https://doi.org/10.3390/jcm10184226

Title: High Oxygen Does Not Increase Reperfusion Injury Assessed with Lipid Peroxidation Biomarkers after Cardiac Arrest : A Post Hoc Analysis of the COMACARE Trial
Author: Humaloja, Jaana; Vento, Maximo; Kuligowski, Julia; Andersson, Sture; Pineiro-Ramos, Jose David; Sanchez-Illana, Angel; Litonius, Erik; Jakkula, Pekka; Hästbacka, Johanna; Bendel, Stepani; Tiainen, Marjaana; Reinikainen, Matti; Skrifvars, Markus B.
Other contributor: University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Clinicum
University of Helsinki, HUS Perioperative, Intensive Care and Pain Medicine
University of Helsinki, HUS Perioperative, Intensive Care and Pain Medicine
University of Helsinki, Clinicum
University of Helsinki, HUS Neurocenter
University of Helsinki, HUS Emergency Medicine and Services









Date: 2021-09
Language: eng
Number of pages: 13
Belongs to series: Journal of clinical medicine
ISSN: 2077-0383
DOI: https://doi.org/10.3390/jcm10184226
URI: http://hdl.handle.net/10138/336549
Abstract: The products of polyunsaturated fatty acid peroxidation are considered reliable biomarkers of oxidative injury in vivo. We investigated ischemia-reperfusion-related oxidative injury by determining the levels of lipid peroxidation biomarkers (isoprostane, isofuran, neuroprostane, and neurofuran) after cardiac arrest and tested the associations between the biomarkers and different arterial oxygen tensions (PaO2). We utilized blood samples collected during the COMACARE trial (NCT02698917). In the trial, 123 patients resuscitated from out-of-hospital cardiac arrest were treated with a 10-15 kPa or 20-25 kPa PaO2 target during the initial 36 h in the intensive care unit. We measured the biomarker levels at admission, and 24, 48, and 72 h thereafter. We compared biomarker levels in the intervention groups and in groups that differed in oxygen exposure prior to randomization. Blood samples for biomarker determination were available for 112 patients. All four biomarker levels peaked at 24 h; the increase appeared greater in younger patients and in patients without bystander-initiated life support. No association between the lipid peroxidation biomarkers and oxygen exposure either before or after randomization was found. Increases in the biomarker levels during the first 24 h in intensive care suggest continuing oxidative stress, but the clinical relevance of this remains unresolved.
Subject: out-of-hospital cardiac arrest
isoprostanes
neuroprostanes
lipid peroxides
reperfusion injury
OXIDATIVE STRESS
CARDIOPULMONARY-RESUSCITATION
MILD HYPOTHERMIA
HEART
ISCHEMIA
INFLAMMATION
METAANALYSIS
ASSOCIATION
METABOLITES
PRODUCTS
3126 Surgery, anesthesiology, intensive care, radiology
3121 General medicine, internal medicine and other clinical medicine
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