Humaloja , J , Vento , M , Kuligowski , J , Andersson , S , Pineiro-Ramos , J D , Sanchez-Illana , A , Litonius , E , Jakkula , P , Hästbacka , J , Bendel , S , Tiainen , M , Reinikainen , M & Skrifvars , M B 2021 , ' High Oxygen Does Not Increase Reperfusion Injury Assessed with Lipid Peroxidation Biomarkers after Cardiac Arrest : A Post Hoc Analysis of the COMACARE Trial ' , Journal of clinical medicine , vol. 10 , no. 18 , 4226 . https://doi.org/10.3390/jcm10184226
Julkaisun nimi: | High Oxygen Does Not Increase Reperfusion Injury Assessed with Lipid Peroxidation Biomarkers after Cardiac Arrest : A Post Hoc Analysis of the COMACARE Trial |
Tekijä: | Humaloja, Jaana; Vento, Maximo; Kuligowski, Julia; Andersson, Sture; Pineiro-Ramos, Jose David; Sanchez-Illana, Angel; Litonius, Erik; Jakkula, Pekka; Hästbacka, Johanna; Bendel, Stepani; Tiainen, Marjaana; Reinikainen, Matti; Skrifvars, Markus B. |
Tekijän organisaatio: | Department of Diagnostics and Therapeutics Clinicum HUS Children and Adolescents HUS Medical Imaging Center HUS Perioperative, Intensive Care and Pain Medicine Anestesiologian yksikkö HUS Neurocenter Neurologian yksikkö Department of Neurosciences HUS Emergency Medicine and Services |
Päiväys: | 2021-09 |
Kieli: | eng |
Sivumäärä: | 13 |
Kuuluu julkaisusarjaan: | Journal of clinical medicine |
ISSN: | 2077-0383 |
DOI-tunniste: | https://doi.org/10.3390/jcm10184226 |
URI: | http://hdl.handle.net/10138/336549 |
Tiivistelmä: | The products of polyunsaturated fatty acid peroxidation are considered reliable biomarkers of oxidative injury in vivo. We investigated ischemia-reperfusion-related oxidative injury by determining the levels of lipid peroxidation biomarkers (isoprostane, isofuran, neuroprostane, and neurofuran) after cardiac arrest and tested the associations between the biomarkers and different arterial oxygen tensions (PaO2). We utilized blood samples collected during the COMACARE trial (NCT02698917). In the trial, 123 patients resuscitated from out-of-hospital cardiac arrest were treated with a 10-15 kPa or 20-25 kPa PaO2 target during the initial 36 h in the intensive care unit. We measured the biomarker levels at admission, and 24, 48, and 72 h thereafter. We compared biomarker levels in the intervention groups and in groups that differed in oxygen exposure prior to randomization. Blood samples for biomarker determination were available for 112 patients. All four biomarker levels peaked at 24 h; the increase appeared greater in younger patients and in patients without bystander-initiated life support. No association between the lipid peroxidation biomarkers and oxygen exposure either before or after randomization was found. Increases in the biomarker levels during the first 24 h in intensive care suggest continuing oxidative stress, but the clinical relevance of this remains unresolved. |
Avainsanat: |
out-of-hospital cardiac arrest
isoprostanes neuroprostanes lipid peroxides reperfusion injury OXIDATIVE STRESS CARDIOPULMONARY-RESUSCITATION MILD HYPOTHERMIA HEART ISCHEMIA INFLAMMATION METAANALYSIS ASSOCIATION METABOLITES PRODUCTS 3126 Surgery, anesthesiology, intensive care, radiology 3121 General medicine, internal medicine and other clinical medicine |
Vertaisarvioitu: | Kyllä |
Tekijänoikeustiedot: | cc_by |
Pääsyrajoitteet: | openAccess |
Rinnakkaistallennettu versio: | publishedVersion |
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