High Oxygen Does Not Increase Reperfusion Injury Assessed with Lipid Peroxidation Biomarkers after Cardiac Arrest : A Post Hoc Analysis of the COMACARE Trial

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dc.contributor.author Humaloja, Jaana
dc.contributor.author Vento, Maximo
dc.contributor.author Kuligowski, Julia
dc.contributor.author Andersson, Sture
dc.contributor.author Pineiro-Ramos, Jose David
dc.contributor.author Sanchez-Illana, Angel
dc.contributor.author Litonius, Erik
dc.contributor.author Jakkula, Pekka
dc.contributor.author Hästbacka, Johanna
dc.contributor.author Bendel, Stepani
dc.contributor.author Tiainen, Marjaana
dc.contributor.author Reinikainen, Matti
dc.contributor.author Skrifvars, Markus B.
dc.date.accessioned 2021-11-19T11:12:01Z
dc.date.available 2021-11-19T11:12:01Z
dc.date.issued 2021-09
dc.identifier.citation Humaloja , J , Vento , M , Kuligowski , J , Andersson , S , Pineiro-Ramos , J D , Sanchez-Illana , A , Litonius , E , Jakkula , P , Hästbacka , J , Bendel , S , Tiainen , M , Reinikainen , M & Skrifvars , M B 2021 , ' High Oxygen Does Not Increase Reperfusion Injury Assessed with Lipid Peroxidation Biomarkers after Cardiac Arrest : A Post Hoc Analysis of the COMACARE Trial ' , Journal of clinical medicine , vol. 10 , no. 18 , 4226 . https://doi.org/10.3390/jcm10184226
dc.identifier.other PURE: 170451108
dc.identifier.other PURE UUID: 0cd0d346-1c0a-4dca-98e7-cf0c22170c9f
dc.identifier.other WOS: 000699642900001
dc.identifier.other ORCID: /0000-0002-3613-7231/work/103471335
dc.identifier.uri http://hdl.handle.net/10138/336549
dc.description.abstract The products of polyunsaturated fatty acid peroxidation are considered reliable biomarkers of oxidative injury in vivo. We investigated ischemia-reperfusion-related oxidative injury by determining the levels of lipid peroxidation biomarkers (isoprostane, isofuran, neuroprostane, and neurofuran) after cardiac arrest and tested the associations between the biomarkers and different arterial oxygen tensions (PaO2). We utilized blood samples collected during the COMACARE trial (NCT02698917). In the trial, 123 patients resuscitated from out-of-hospital cardiac arrest were treated with a 10-15 kPa or 20-25 kPa PaO2 target during the initial 36 h in the intensive care unit. We measured the biomarker levels at admission, and 24, 48, and 72 h thereafter. We compared biomarker levels in the intervention groups and in groups that differed in oxygen exposure prior to randomization. Blood samples for biomarker determination were available for 112 patients. All four biomarker levels peaked at 24 h; the increase appeared greater in younger patients and in patients without bystander-initiated life support. No association between the lipid peroxidation biomarkers and oxygen exposure either before or after randomization was found. Increases in the biomarker levels during the first 24 h in intensive care suggest continuing oxidative stress, but the clinical relevance of this remains unresolved. en
dc.format.extent 13
dc.language.iso eng
dc.relation.ispartof Journal of clinical medicine
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject out-of-hospital cardiac arrest
dc.subject isoprostanes
dc.subject neuroprostanes
dc.subject lipid peroxides
dc.subject reperfusion injury
dc.subject OXIDATIVE STRESS
dc.subject CARDIOPULMONARY-RESUSCITATION
dc.subject MILD HYPOTHERMIA
dc.subject HEART
dc.subject ISCHEMIA
dc.subject INFLAMMATION
dc.subject METAANALYSIS
dc.subject ASSOCIATION
dc.subject METABOLITES
dc.subject PRODUCTS
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title High Oxygen Does Not Increase Reperfusion Injury Assessed with Lipid Peroxidation Biomarkers after Cardiac Arrest : A Post Hoc Analysis of the COMACARE Trial en
dc.type Article
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization Clinicum
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization HUS Medical Imaging Center
dc.contributor.organization HUS Perioperative, Intensive Care and Pain Medicine
dc.contributor.organization Anestesiologian yksikkö
dc.contributor.organization HUS Neurocenter
dc.contributor.organization Neurologian yksikkö
dc.contributor.organization Department of Neurosciences
dc.contributor.organization HUS Emergency Medicine and Services
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3390/jcm10184226
dc.relation.issn 2077-0383
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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