Eukaryotic translation elongation factor 1 delta, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients

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Domingueti , C B , Queiroz Castilho , D A , de Oliveira , C E , Macuco Janini , J B , Gonzalez-Arriagada , W A , Salo , T , Coletta , R D & Ribeiro Paranaiba , L M 2020 , ' Eukaryotic translation elongation factor 1 delta, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients ' , Oral surgery, oral medicine, oral pathology and oral radiology , vol. 130 , no. 6 , pp. 700-+ . https://doi.org/10.1016/j.oooo.2020.09.003

Title: Eukaryotic translation elongation factor 1 delta, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients
Author: Domingueti, Catherine Bueno; Queiroz Castilho, Dayana Aparecida; de Oliveira, Carine Ervolino; Macuco Janini, joao Baptista; Gonzalez-Arriagada, Wilfredo Alejandro; Salo, Tuula; Coletta, Ricardo D.; Ribeiro Paranaiba, Livia Maris
Contributor: University of Helsinki, HUSLAB
Date: 2020-12
Language: eng
Number of pages: 10
Belongs to series: Oral surgery, oral medicine, oral pathology and oral radiology
ISSN: 2212-4403
URI: http://hdl.handle.net/10138/336566
Abstract: Objective. Identifying markers that influence oral squamous cell carcinoma (OSCC) prognosis is a fundamental strategy to improve the overall survival of patients. Markers such as eukaryotic translation elongation factor 1 delta (EEF1D), fascin, N-terminal propeptide of type I collagen (PINP), and cancer-associated fibroblasts (CAFs) have been noticed in OSCCs and their levels are closely related to the prognosis of tumors. Our aim was to confirm the role of those markers in OSCC prognosis. Study Design. Immunohistochemistry was performed in 90 OSCC specimens. The associations between clinicopathologic features and expression of markers were assessed by chi(2) test. Kaplan-Meier curves and univariate and multivariate Cox regression models were used for survival analysis. Markers were analyzed individually and in combination. Results. High expression of EEF1D (P =.017) and PINP (P =.02) and abundant density of CAFs in tumor stroma (P =.005) predicted significantly poor survival in OSCC patients. Multivariate analysis revealed that all 3 parameters are individually independent prognostic factors of OSCC patients, and their combination improved the discrimination of patients at high risk for poor survival. Conclusions. Our results suggested that the expression of EEF1D and PINP and the density of CAFs might influence the survival of patients with OSCC.
Subject: AMERICAN JOINT COMMITTEE
FASCIN OVER-EXPRESSION
LYMPH-NODE METASTASIS
EXTRACELLULAR-MATRIX
TONGUE
MYOFIBROBLASTS
PROLIFERATION
PREDICTOR
PHENOTYPE
313 Dentistry
3126 Surgery, anesthesiology, intensive care, radiology
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