The genetic background of the associations between sense of coherence and mental health, self-esteem and personality

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http://hdl.handle.net/10138/336590

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Silventoinen , K , Vuoksimaa , E , Volanen , SM , Palviainen , T , Rose , RJ , Suominen , S & Kaprio , J 2021 , ' The genetic background of the associations between sense of coherence and mental health, self-esteem and personality ' , Social Psychiatry and Psychiatric Epidemiology . https://doi.org/10.1007/s00127-021-02098-6

Julkaisun nimi: The genetic background of the associations between sense of coherence and mental health, self-esteem and personality
Tekijä: Silventoinen, K; Vuoksimaa, E; Volanen, SM; Palviainen, T; Rose, RJ; Suominen, S; Kaprio, J
Tekijän organisaatio: Helsinki Inequality Initiative (INEQ)
Doctoral Programme in Social Sciences
Demography
Doctoral Programme in Population Health
Population Research Unit (PRU)
Center for Population, Health and Society
Sociology
Cognitive and Brain Aging
Doctoral Programme Brain & Mind
Institute for Molecular Medicine Finland
Clinicum
Department of Public Health
Genetic Epidemiology
Päiväys: 2021-05
Kieli: eng
Kuuluu julkaisusarjaan: Social Psychiatry and Psychiatric Epidemiology
ISSN: 0933-7954
DOI-tunniste: https://doi.org/10.1007/s00127-021-02098-6
URI: http://hdl.handle.net/10138/336590
Tiivistelmä: Purpose Sense of coherence (SOC) represents coping and can be considered an essential component of mental health. SOC correlates with mental health and personality, but the background of these associations is poorly understood. We analyzed the role of genetic factors behind the associations of SOC with mental health, self-esteem and personality using genetic twin modeling and polygenic scores (PGS). Methods Information on SOC (13-item Orientation of Life Questionnaire), four mental health indicators, self-esteem and personality (NEO Five Factor Inventory Questionnaire) was collected from 1295 Finnish twins at 20-27 years of age. Results In men and women, SOC correlated negatively with depression, alexithymia, schizotypal personality and overall mental health problems and positively with self-esteem. For personality factors, neuroticism was associated with weaker SOC and extraversion, agreeableness and conscientiousness with stronger SOC. All these psychological traits were influenced by genetic factors with heritability estimates ranging from 19 to 66%. Genetic and environmental factors explained these associations, but the genetic correlations were generally stronger. The PGS of major depressive disorder was associated with weaker, and the PGS of general risk tolerance with stronger SOC in men, whereas in women the PGS of subjective well-being was associated with stronger SOC and the PGSs of depression and neuroticism with weaker SOC. Conclusion Our results indicate that a substantial proportion of genetic variation in SOC is shared with mental health, self-esteem and personality indicators. This suggests that the correlations between these traits reflect a common neurobiological background rather than merely the influence of external stressors.
Avainsanat: Sense of coherence
Mental health
Personality
Twins
Polygenic score
ANTONOVSKYS SENSE
ENVIRONMENTAL-FACTORS
DEPRESSIVE SYMPTOMS
SCALE
TWIN
HERITABILITY
ALEXITHYMIA
CHILDHOOD
ADULTHOOD
LIFE
3142 Public health care science, environmental and occupational health
Vertaisarvioitu: Kyllä
Tekijänoikeustiedot: cc_by
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: publishedVersion


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